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Besides an ITIM/SHP-1-dependent pathway, CD22 collaborates with Grb2 and plasma membrane calcium-ATPase in an ITIM/SHP-1-independent pathway of attenuation of Ca(2+)(i) signal in B cells

CD22 is a surface immunoglobulin implicated in negative regulation of B cell receptor (BCR) signaling; particularly inhibiting intracellular Ca(2+) (Ca(2+)(i))signals. Its cytoplasmic tail contains six tyrosine residues (Y773/Y783/Y817/Y828/Y843/Y863, designated Y1~Y6 respectively), including three...

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Detalles Bibliográficos
Autores principales:	Chen, Jie, Wang, Hong, Xu, Wei-Ping, Wei, Si-Si, Li, Hui Joyce, Mei, Yun-Qing, Li, Yi-Gang, Wang, Yue-Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302901/ https://www.ncbi.nlm.nih.gov/pubmed/27276708 http://dx.doi.org/10.18632/oncotarget.9794

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