Mechanism of BRG1 silencing in primary cancers

BRG1 (SMARCA4) is a documented tumor suppressor and a key subunit of the SWI/SNF chromatin remodeling complex that is silenced in many cancer types. Studies have shown that BRG1 is mutated in cancer-derived cell lines, which led to the assertion that BRG1 is also mutated in primary human tumors. How...

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Detalles Bibliográficos
Autores principales: Marquez, Stefanie B., Thompson, Kenneth, Lu, Li, Reisman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302903/
https://www.ncbi.nlm.nih.gov/pubmed/27486753
http://dx.doi.org/10.18632/oncotarget.10593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302903/
https://www.ncbi.nlm.nih.gov/pubmed/27486753
http://dx.doi.org/10.18632/oncotarget.10593

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