Smac mimetic LCL161 overcomes protective ER stress induced by obatoclax, synergistically causing cell death in multiple myeloma

Bcl2 and IAP families are anti-apoptotic proteins deregulated in multiple myeloma (MM) cells. Pharmacological inhibition of each of these families has shown significant activity only in subgroups of MM patients. Here, we have examined a broad-spectrum Bcl2 family inhibitor Obatoclax (OBX) in combina...

Descripción completa

Detalles Bibliográficos
Autores principales: Ramakrishnan, Vijay, Gomez, Marcus, Prasad, Vivek, Kimlinger, Teresa, Painuly, Utkarsh, Mukhopadhyay, Bedabrata, Haug, Jessica, Bi, Lintao, Rajkumar, S. Vincent, Kumar, Shaji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302912/
https://www.ncbi.nlm.nih.gov/pubmed/27494845
http://dx.doi.org/10.18632/oncotarget.11028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302912/
https://www.ncbi.nlm.nih.gov/pubmed/27494845
http://dx.doi.org/10.18632/oncotarget.11028

Ejemplares similares