Loss of MYC and E-box3 binding contributes to defective MYC-mediated transcriptional suppression of human MC-let-7a-1~let-7d in glioblastoma

Previously, we reported that MYC oncoprotein down-regulates the transcription of human MC-let-7a-1~let-7d microRNA cluster in hepatocarcinoma (HCC). Surprisingly, in silico analysis indicated that let-7 miRNA expression levels are not reduced in glioblastoma (GBM). Here we investigated the molecular...

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Detalles Bibliográficos
Autores principales: Wang, Zifeng, Lin, Sheng, Zhang, Ji, Xu, Zhenhua, Xiang, Yu, Yao, Hong, Ge, Lei, Xie, Dan, Kung, Hsiang-fu, Lu, Gang, Poon, Wai Sang, Liu, Quentin, Lin, Marie Chia-mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302913/
https://www.ncbi.nlm.nih.gov/pubmed/27409345
http://dx.doi.org/10.18632/oncotarget.10517

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