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Association of the GLB1 rs4678680 genetic variant with risk of HBV-related hepatocellular carcinoma

Accumulated evidences demonstrated that GLB1 is involved in cell senescence and cancer development. The GLB1 rs4678680 single nucleotide polymorphism (SNP) has been identified as a hepatocellular carcinoma (HCC) susceptibility polymorphism by a genome-wide association study in Korean population prev...

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Autores principales: Wang, Wen-Tao, Li, Ziqiang, Shi, Meng, Zhu, Hui, Xiong, Xiangyu, Shang, Jinhua, Liu, Jibing, Teng, Mujian, Yang, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302931/
https://www.ncbi.nlm.nih.gov/pubmed/27489354
http://dx.doi.org/10.18632/oncotarget.10963
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author Wang, Wen-Tao
Li, Ziqiang
Shi, Meng
Zhu, Hui
Xiong, Xiangyu
Shang, Jinhua
Liu, Jibing
Teng, Mujian
Yang, Ming
author_facet Wang, Wen-Tao
Li, Ziqiang
Shi, Meng
Zhu, Hui
Xiong, Xiangyu
Shang, Jinhua
Liu, Jibing
Teng, Mujian
Yang, Ming
author_sort Wang, Wen-Tao
collection PubMed
description Accumulated evidences demonstrated that GLB1 is involved in cell senescence and cancer development. The GLB1 rs4678680 single nucleotide polymorphism (SNP) has been identified as a hepatocellular carcinoma (HCC) susceptibility polymorphism by a genome-wide association study in Korean population previously. However, little or nothing was known about its involvement and functional significance in hepatitis B viruses (HBV)-related HCC in Chinese. Therefore, we investigated the association between the GLB1 rs4678680 SNP and HBV-related HCC risk as well as its biological function in vivo. Genotypes were determined in two independent case-control sets from two medical centers of China. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by logistic regression. The potential regulation role the rs4678680 genetic variant on GLB1 expression was examined with HCC and normal liver tissues. We found that The rs4678680 G allele was showed to be risk allele; individuals with the TG genotype had an OR of 1.51 (95% CI = 1.10–2.07, P = 0.010, Shandong set) or 1.49 (95% CI = 1.11–1.99, P = 0.008, Jiangsu set) for developing HBV-related HCC, respectively, compared with individuals with the TT genotype. This association was more pronounced in males, individuals aged older than 57 years and drinkers (all P < 0.05). In the genotype-phenotype correlation analyses of fifty-six human liver tissue samples, rs4678680 TG or GG was associated with a statistically significant increase of GLB1 mRNA expression (P < 0.05). Our data indicated that the GLB1 rs4678680 SNP contributes to susceptibility to develop HBV-related HCC, highlighting the involvement of GLB1 and cell senescence in etiology of HCC.
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spelling pubmed-53029312017-02-13 Association of the GLB1 rs4678680 genetic variant with risk of HBV-related hepatocellular carcinoma Wang, Wen-Tao Li, Ziqiang Shi, Meng Zhu, Hui Xiong, Xiangyu Shang, Jinhua Liu, Jibing Teng, Mujian Yang, Ming Oncotarget Research Paper Accumulated evidences demonstrated that GLB1 is involved in cell senescence and cancer development. The GLB1 rs4678680 single nucleotide polymorphism (SNP) has been identified as a hepatocellular carcinoma (HCC) susceptibility polymorphism by a genome-wide association study in Korean population previously. However, little or nothing was known about its involvement and functional significance in hepatitis B viruses (HBV)-related HCC in Chinese. Therefore, we investigated the association between the GLB1 rs4678680 SNP and HBV-related HCC risk as well as its biological function in vivo. Genotypes were determined in two independent case-control sets from two medical centers of China. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by logistic regression. The potential regulation role the rs4678680 genetic variant on GLB1 expression was examined with HCC and normal liver tissues. We found that The rs4678680 G allele was showed to be risk allele; individuals with the TG genotype had an OR of 1.51 (95% CI = 1.10–2.07, P = 0.010, Shandong set) or 1.49 (95% CI = 1.11–1.99, P = 0.008, Jiangsu set) for developing HBV-related HCC, respectively, compared with individuals with the TT genotype. This association was more pronounced in males, individuals aged older than 57 years and drinkers (all P < 0.05). In the genotype-phenotype correlation analyses of fifty-six human liver tissue samples, rs4678680 TG or GG was associated with a statistically significant increase of GLB1 mRNA expression (P < 0.05). Our data indicated that the GLB1 rs4678680 SNP contributes to susceptibility to develop HBV-related HCC, highlighting the involvement of GLB1 and cell senescence in etiology of HCC. Impact Journals LLC 2016-07-30 /pmc/articles/PMC5302931/ /pubmed/27489354 http://dx.doi.org/10.18632/oncotarget.10963 Text en Copyright: © 2016 Wang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Wang, Wen-Tao
Li, Ziqiang
Shi, Meng
Zhu, Hui
Xiong, Xiangyu
Shang, Jinhua
Liu, Jibing
Teng, Mujian
Yang, Ming
Association of the GLB1 rs4678680 genetic variant with risk of HBV-related hepatocellular carcinoma
title Association of the GLB1 rs4678680 genetic variant with risk of HBV-related hepatocellular carcinoma
title_full Association of the GLB1 rs4678680 genetic variant with risk of HBV-related hepatocellular carcinoma
title_fullStr Association of the GLB1 rs4678680 genetic variant with risk of HBV-related hepatocellular carcinoma
title_full_unstemmed Association of the GLB1 rs4678680 genetic variant with risk of HBV-related hepatocellular carcinoma
title_short Association of the GLB1 rs4678680 genetic variant with risk of HBV-related hepatocellular carcinoma
title_sort association of the glb1 rs4678680 genetic variant with risk of hbv-related hepatocellular carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302931/
https://www.ncbi.nlm.nih.gov/pubmed/27489354
http://dx.doi.org/10.18632/oncotarget.10963
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