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IGF-1R inhibition sensitizes breast cancer cells to ATM-related kinase (ATR) inhibitor and cisplatin

The complexity of the IGF-1 signalling axis is clearly a roadblock in targeting this receptor in cancer therapy. Here, we sought to identify mediators of resistance, and potential co-targets for IGF-1R inhibition. By using an siRNA functional screen with the IGF-1R tyrosine kinase inhibitor (TKI) BM...

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Detalles Bibliográficos
Autores principales:	O'Flanagan, Ciara H., O'shea, Sandra, Lyons, Amy, Fogarty, Fionola M., McCabe, Nuala, Kennedy, Richard D., O'Connor, Rosemary
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302955/ https://www.ncbi.nlm.nih.gov/pubmed/27472395 http://dx.doi.org/10.18632/oncotarget.10862

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