Functional single nucleotide polymorphisms within the cyclin-dependent kinase inhibitor 2A/2B region affect pancreatic cancer risk

The CDKN2A (p16) gene plays a key role in pancreatic cancer etiology. It is one of the most commonly somatically mutated genes in pancreatic cancer, rare germline mutations have been found to be associated with increased risk of developing familiar pancreatic cancer and CDKN2A promoter hyper-methyla...

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Autores principales: Campa, Daniele, Pastore, Manuela, Gentiluomo, Manuel, Talar-Wojnarowska, Renata, Kupcinskas, Juozas, Malecka-Panas, Ewa, Neoptolemos, John P., Niesen, Willem, Vodicka, Pavel, Fave, Gianfranco Delle, Bueno-de-Mesquita, H. Bas, Gazouli, Maria, Pacetti, Paola, Di Leo, Milena, Ito, Hidemi, Klüter, Harald, Soucek, Pavel, Corbo, Vincenzo, Yamao, Kenji, Hosono, Satoyo, Kaaks, Rudolf, Vashist, Yogesh, Gioffreda, Domenica, Strobel, Oliver, Shimizu, Yasuhiro, Dijk, Frederike, Andriulli, Angelo, Ivanauskas, Audrius, Bugert, Peter, Tavano, Francesca, Vodickova, Ludmila, Zambon, Carlo Federico, Lovecek, Martin, Landi, Stefano, Key, Timothy J., Boggi, Ugo, Pezzilli, Raffaele, Jamroziak, Krzysztof, Mohelnikova-Duchonova, Beatrice, Mambrini, Andrea, Bambi, Franco, Busch, Olivier, Pazienza, Valerio, Valente, Roberto, Theodoropoulos, George E., Hackert, Thilo, Capurso, Gabriele, Cavestro, Giulia Martina, Pasquali, Claudio, Basso, Daniela, Sperti, Cosimo, Matsuo, Keitaro, Büchler, Markus, Khaw, Kay-Tee, Izbicki, Jakob, Costello, Eithne, Katzke, Verena, Michalski, Christoph, Stepien, Anna, Rizzato, Cosmeri, Canzian, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302969/
https://www.ncbi.nlm.nih.gov/pubmed/27486979
http://dx.doi.org/10.18632/oncotarget.10935

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