Expression of the p66Shc protein adaptor is regulated by the activator of transcription STAT4 in normal and chronic lymphocytic leukemia B cells

p66Shc attenuates mitogenic, prosurvival and chemotactic signaling and promotes apoptosis in lymphocytes. Consistently, p66Shc deficiency contributes to the survival and trafficking abnormalities of chronic lymphocytic leukemia (CLL) B cells. The mechanism of p66shc silencing in CLL B cells is methy...

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Detalles Bibliográficos
Autores principales: Cattaneo, Francesca, Patrussi, Laura, Capitani, Nagaja, Frezzato, Federica, D'Elios, Mario Milco, Trentin, Livio, Semenzato, Gianpietro, Baldari, Cosima T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302975/
https://www.ncbi.nlm.nih.gov/pubmed/27494881
http://dx.doi.org/10.18632/oncotarget.10977

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