Structural determinants of the hyperalgesic activity of myotoxic Lys49-phospholipase A(2)

BACKGROUND: Bothropstoxin-I (BthTx-I) is a Lys49-phospholipase A(2) (Lys49-PLA(2)) from the venom of Bothrops jararacussu, which despite of the lack of catalytic activity induces myotoxicity, inflammation and pain. The C-terminal region of the Lys49-PLA(2)s is important for these effects; however, t...

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Detalles Bibliográficos
Autores principales: Zambelli, Vanessa Olzon, Chioato, Lucimara, Gutierrez, Vanessa Pacciari, Ward, Richard John, Cury, Yara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303236/
https://www.ncbi.nlm.nih.gov/pubmed/28203248
http://dx.doi.org/10.1186/s40409-017-0099-6

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