Cargando…

Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance

BACKGROUND: Retinoid therapy is widely employed in clinical oncology to differentiate malignant cells into their more benign counterparts. However, certain high-risk cohorts, such as patients with MYCN-amplified neuroblastoma, are innately resistant to retinoid therapy. Therefore, we employed a prec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Duffy, David J., Krstic, Aleksandar, Halasz, Melinda, Schwarzl, Thomas, Konietzny, Anja, Iljin, Kristiina, Higgins, Desmond G., Kolch, Walter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303304/ https://www.ncbi.nlm.nih.gov/pubmed/28187790 http://dx.doi.org/10.1186/s13073-017-0407-3

Ejemplares similares

A Chemo-Genomic Approach Identifies Diverse Epigenetic Therapeutic Vulnerabilities in MYCN-Amplified Neuroblastoma
por: Krstic, Aleksandar, et al.
Publicado: (2021)

Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma
por: Duffy, David J., et al.
Publicado: (2015)

Wnt signalling is a bi-directional vulnerability of cancer cells
por: Duffy, David J., et al.
Publicado: (2016)

Transcriptional profiling of early differentiation of primary human mesenchymal stem cells into chondrocytes
por: Schwarzl, Thomas, et al.
Publicado: (2023)

Retinoic Acid and Retinoid X Receptors
por: Schubert, Michael, et al.
Publicado: (2023)

EMBO Retinoids 2011: mechanisms, biology and pathology of signaling by retinoic acid and retinoic acid receptors
por: McKenna, Neil J.
Publicado: (2012)

Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid
por: Qin, Xian-Yang, et al.
Publicado: (2018)

Regulation of Retinoid Receptors by Retinoic Acid and Axonal Contact in Schwann Cells
por: Latasa, Maria-Jesus, et al.
Publicado: (2011)

The MYCN inhibitor BGA002 restores the retinoic acid response leading to differentiation or apoptosis by the mTOR block in MYCN-amplified neuroblastoma
por: Lampis, Silvia, et al.
Publicado: (2022)

Enhancement of Efficacy of Retinoids through Enhancing Retinoid-Induced RAR Activity and Inhibiting Hydroxylation of Retinoic Acid, and Its Clinical Efficacy on Photo-Aging
por: Kang, Seongsu, et al.
Publicado: (2022)

Roles of Retinoids and Retinoic Acid Receptors in the Regulation of Hematopoietic Stem Cell Self-Renewal and Differentiation
por: E. Purton, Louise
Publicado: (2007)

Identifying the receptor subtype selectivity of retinoid X and retinoic acid receptors via quantum mechanics
por: Tsuji, Motonori, et al.
Publicado: (2017)

Identification of Retinoic Acid in a High Content Screen for Agents that Overcome the Anti-Myogenic Effect of TGF-Beta-1
por: Krueger, Chateen, et al.
Publicado: (2010)

Bovine cumulus-granulosa cells contain biologically active retinoid receptors that can respond to retinoic acid
por: Mohan, Mahesh, et al.
Publicado: (2003)

Expression mRNA pattern of retinoic acid and retinoid X nuclear receptor subtypes in thyroid carcinomas
por: Brtko, Julius, et al.
Publicado: (2013)

Retinoic Acid Receptor and Retinoid × Receptor in Ductal Carcinoma in situ and Intraductal Proliferative Lesions of the Human Breast
por: Ariga, Naohiro, et al.
Publicado: (2000)

Clozapine modulates retinoid homeostasis in human brain and normalizes serum retinoic acid deficit in patients with schizophrenia
por: Regen, Francesca, et al.
Publicado: (2020)

MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma
por: Lodrini, Marco, et al.
Publicado: (2013)

Analysis of Alternative mRNA Splicing in Vemurafenib-Resistant Melanoma Cells
por: Bokharaie, Honey, et al.
Publicado: (2022)

Retinoid X Receptor Agonists Upregulate Genes Responsible for the Biosynthesis of All-Trans-Retinoic Acid in Human Epidermis
por: Wu, Lizhi, et al.
Publicado: (2016)

Retinoic acid receptor alpha drives cell cycle progression and is associated with increased sensitivity to retinoids in T-cell lymphoma
por: Wang, Xueju, et al.
Publicado: (2017)

Retinoic Acid Grafted to Hyaluronic Acid Activates Retinoid Gene Expression and Removes Cholesterol from Cellular Membranes
por: Pavlík, Vojtěch, et al.
Publicado: (2022)

MYCN and the epigenome
por: He, Stanley, et al.
Publicado: (2013)

The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice
por: Schoof, Melanie, et al.
Publicado: (2023)

Retinoic Acid Mediates Long-Paced Oscillations in Retinoid Receptor Activity: Evidence for a Potential Role for RIP140
por: Heim, Kelly C., et al.
Publicado: (2009)

MYCN and PRC1 cooperatively repress docosahexaenoic acid synthesis in neuroblastoma via ELOVL2
por: Ding, Yi, et al.
Publicado: (2019)

Of Retinoids and Organotins: The Evolution of the Retinoid X Receptor in Metazoa
por: Fonseca, Elza, et al.
Publicado: (2020)

MYCN is amplified during S phase, and c-myb is involved in controlling MYCN expression and amplification in MYCN-amplified neuroblastoma cell lines
por: Aygun, Nevim, et al.
Publicado: (2019)

Retinoic acid receptors in retinoid responsive ovarian cancer cell lines detected by polymerase chain reaction following reverse transcription.
por: Harant, H., et al.
Publicado: (1993)

Retinoid metabolism and all-trans retinoic acid-induced growth inhibition in head and neck squamous cell carcinoma cell lines.
por: Braakhuis, B. J., et al.
Publicado: (1997)

Implementation of the plasma MYCN/NAGK ratio to detect MYCN amplification in patients with neuroblastoma
por: Su, Yan, et al.
Publicado: (2020)

MYCN upregulates the transsulfuration pathway to suppress the ferroptotic vulnerability in MYCN-amplified neuroblastoma
por: Floros, Konstantinos V., et al.
Publicado: (2022)

Retinoids in Oncology
por: Rustin, G.J.S.
Publicado: (1994)

2-Bromopalmitate targets retinoic acid receptor alpha and overcomes all-trans retinoic acid resistance of acute promyelocytic leukemia
por: Lu, Ying, et al.
Publicado: (2019)

Retinoic acid receptor alpha mediates growth inhibition by retinoids in rat pancreatic carcinoma DSL-6A/C1 cells.
por: Brembeck, F. H., et al.
Publicado: (1998)

Antigene MYCN Silencing by BGA002 Inhibits SCLC Progression Blocking mTOR Pathway and Overcomes Multidrug Resistance
por: Bortolotti, Sonia, et al.
Publicado: (2023)

MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma
por: Agarwal, Saurabh, et al.
Publicado: (2018)

Therapeutic potential of targeting MYCN: A case series report of neuroblastoma with MYCN amplification
por: Huang, Can, et al.
Publicado: (2020)

A MYCN-independent mechanism mediating secretome reprogramming and metastasis in MYCN-amplified neuroblastoma
por: Zhang, Hai-Feng, et al.
Publicado: (2023)

Correlation Between MYCN Gene Status and MYCN Protein Expression in Neuroblastoma: A Pilot Study To Propose the Use of MYCN Immunohistochemistry in Limited-Resource Areas
por: Santiago, Teresa, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_73bkprlo0o8fn29r8jq6r6pebk