High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH(2)) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5

TIP39 (“tuberoinfundibular peptide of 39 residues”) acts via the parathyroid hormone 2 receptor, PTH(2), a Family B G protein-coupled receptor (GPCR). Despite the importance of GPCRs in human physiology and pharmacotherapy, little is known about the molecular details of the TIP39-PTH(2) interaction....

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Detalles Bibliográficos
Autores principales: Weaver, Richard E., Mobarec, Juan C., Wigglesworth, Mark J., Reynolds, Christopher A., Donnelly, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303546/
https://www.ncbi.nlm.nih.gov/pubmed/28012961
http://dx.doi.org/10.1016/j.bcp.2016.12.013

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