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Pediatric TSH Reference Intervals and Prevalence of High Thyroid Antibodies in the Lebanese Population
The aims of this study are to establish reference values for TSH in Lebanese schoolchildren; to look at the relationship between TSH and age, gender, BMI, socioeconomic status (SES), and thyroid antibodies (TAb); and to investigate the prevalence of abnormal TAb in this population. 974 Lebanese scho...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303574/ https://www.ncbi.nlm.nih.gov/pubmed/28250769 http://dx.doi.org/10.1155/2017/6372964 |
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author | Gannagé-Yared, Marie-Hélène Balech, Nicole Farah, Vanessa Antar, Marianne Saliba, Rindala Chahine, Elise |
author_facet | Gannagé-Yared, Marie-Hélène Balech, Nicole Farah, Vanessa Antar, Marianne Saliba, Rindala Chahine, Elise |
author_sort | Gannagé-Yared, Marie-Hélène |
collection | PubMed |
description | The aims of this study are to establish reference values for TSH in Lebanese schoolchildren; to look at the relationship between TSH and age, gender, BMI, socioeconomic status (SES), and thyroid antibodies (TAb); and to investigate the prevalence of abnormal TAb in this population. 974 Lebanese schoolchildren aged 8–18 years were recruited from 10 schools of different SES. Third-generation TSH, TPO-Ab, and Tg-Ab measurements were performed using the IMMULITE chemiluminescent immunoassay. The mean TSH is 2.06 ± 1.05 μUI/ml. TSH values are inversely correlated with age (p < 0.0001), are higher in boys than in girls (resp., 2.14 ± 1.10 and 1.98 ± 0.99 μUI/ml, p = 0.017), and are positively correlated with BMI (p < 0.0001). They are also significantly higher in subjects from low-SES schools (p = 0.03) and in girls with positive TAb (p = 0.026). In boys, TSH is independently associated with age, BMI, and schools' SES (p = 0.01, p = 0.03, and p = 0.026, resp.) while in girls, the association is only significant for age and TAb (p = 0.0001 and p = 0.015, resp.). The prevalence of TAb is 4.3% (3% for TPO-Ab and 2.1% for Tg-Ab). Our results showed higher TSH values in the pediatric Lebanese population compared to western populations. TSH varies according to age, gender, BMI, and SES and is associated in girls with TAb. |
format | Online Article Text |
id | pubmed-5303574 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-53035742017-03-01 Pediatric TSH Reference Intervals and Prevalence of High Thyroid Antibodies in the Lebanese Population Gannagé-Yared, Marie-Hélène Balech, Nicole Farah, Vanessa Antar, Marianne Saliba, Rindala Chahine, Elise Int J Endocrinol Research Article The aims of this study are to establish reference values for TSH in Lebanese schoolchildren; to look at the relationship between TSH and age, gender, BMI, socioeconomic status (SES), and thyroid antibodies (TAb); and to investigate the prevalence of abnormal TAb in this population. 974 Lebanese schoolchildren aged 8–18 years were recruited from 10 schools of different SES. Third-generation TSH, TPO-Ab, and Tg-Ab measurements were performed using the IMMULITE chemiluminescent immunoassay. The mean TSH is 2.06 ± 1.05 μUI/ml. TSH values are inversely correlated with age (p < 0.0001), are higher in boys than in girls (resp., 2.14 ± 1.10 and 1.98 ± 0.99 μUI/ml, p = 0.017), and are positively correlated with BMI (p < 0.0001). They are also significantly higher in subjects from low-SES schools (p = 0.03) and in girls with positive TAb (p = 0.026). In boys, TSH is independently associated with age, BMI, and schools' SES (p = 0.01, p = 0.03, and p = 0.026, resp.) while in girls, the association is only significant for age and TAb (p = 0.0001 and p = 0.015, resp.). The prevalence of TAb is 4.3% (3% for TPO-Ab and 2.1% for Tg-Ab). Our results showed higher TSH values in the pediatric Lebanese population compared to western populations. TSH varies according to age, gender, BMI, and SES and is associated in girls with TAb. Hindawi Publishing Corporation 2017 2017-01-18 /pmc/articles/PMC5303574/ /pubmed/28250769 http://dx.doi.org/10.1155/2017/6372964 Text en Copyright © 2017 Marie-Hélène Gannagé-Yared et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Gannagé-Yared, Marie-Hélène Balech, Nicole Farah, Vanessa Antar, Marianne Saliba, Rindala Chahine, Elise Pediatric TSH Reference Intervals and Prevalence of High Thyroid Antibodies in the Lebanese Population |
title | Pediatric TSH Reference Intervals and Prevalence of High Thyroid Antibodies in the Lebanese Population |
title_full | Pediatric TSH Reference Intervals and Prevalence of High Thyroid Antibodies in the Lebanese Population |
title_fullStr | Pediatric TSH Reference Intervals and Prevalence of High Thyroid Antibodies in the Lebanese Population |
title_full_unstemmed | Pediatric TSH Reference Intervals and Prevalence of High Thyroid Antibodies in the Lebanese Population |
title_short | Pediatric TSH Reference Intervals and Prevalence of High Thyroid Antibodies in the Lebanese Population |
title_sort | pediatric tsh reference intervals and prevalence of high thyroid antibodies in the lebanese population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303574/ https://www.ncbi.nlm.nih.gov/pubmed/28250769 http://dx.doi.org/10.1155/2017/6372964 |
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