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Current Perspectives on In Vivo Noninvasive Tracking of Extracellular Vesicles with Molecular Imaging

Clinical and preclinical in vivo tracking of extracellular vesicles (EVs) are a crucial tool for the development and optimization of EV-based diagnosis and treatment. EVs have gained interest due to their unique properties that make them excellent candidates for biological applications. Noninvasive...

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Detalles Bibliográficos
Autores principales: Gangadaran, Prakash, Hong, Chae Moon, Ahn, Byeong-Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303595/
https://www.ncbi.nlm.nih.gov/pubmed/28246609
http://dx.doi.org/10.1155/2017/9158319
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author Gangadaran, Prakash
Hong, Chae Moon
Ahn, Byeong-Cheol
author_facet Gangadaran, Prakash
Hong, Chae Moon
Ahn, Byeong-Cheol
author_sort Gangadaran, Prakash
collection PubMed
description Clinical and preclinical in vivo tracking of extracellular vesicles (EVs) are a crucial tool for the development and optimization of EV-based diagnosis and treatment. EVs have gained interest due to their unique properties that make them excellent candidates for biological applications. Noninvasive in vivo EV tracking has allowed marked progress towards elucidating the mechanisms and functions of EVs in real time in preclinical and clinical studies. In this review, we summarize several molecular imaging methods that deal with EVs derived from different cells, which have allowed investigations of EV biodistribution, as well as their tracking, delivery, and tumor targeting, to determine their physiological functions and to exploit imaging-derived information for EV-based theranostics.
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spelling pubmed-53035952017-02-28 Current Perspectives on In Vivo Noninvasive Tracking of Extracellular Vesicles with Molecular Imaging Gangadaran, Prakash Hong, Chae Moon Ahn, Byeong-Cheol Biomed Res Int Review Article Clinical and preclinical in vivo tracking of extracellular vesicles (EVs) are a crucial tool for the development and optimization of EV-based diagnosis and treatment. EVs have gained interest due to their unique properties that make them excellent candidates for biological applications. Noninvasive in vivo EV tracking has allowed marked progress towards elucidating the mechanisms and functions of EVs in real time in preclinical and clinical studies. In this review, we summarize several molecular imaging methods that deal with EVs derived from different cells, which have allowed investigations of EV biodistribution, as well as their tracking, delivery, and tumor targeting, to determine their physiological functions and to exploit imaging-derived information for EV-based theranostics. Hindawi Publishing Corporation 2017 2017-01-29 /pmc/articles/PMC5303595/ /pubmed/28246609 http://dx.doi.org/10.1155/2017/9158319 Text en Copyright © 2017 Prakash Gangadaran et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gangadaran, Prakash
Hong, Chae Moon
Ahn, Byeong-Cheol
Current Perspectives on In Vivo Noninvasive Tracking of Extracellular Vesicles with Molecular Imaging
title Current Perspectives on In Vivo Noninvasive Tracking of Extracellular Vesicles with Molecular Imaging
title_full Current Perspectives on In Vivo Noninvasive Tracking of Extracellular Vesicles with Molecular Imaging
title_fullStr Current Perspectives on In Vivo Noninvasive Tracking of Extracellular Vesicles with Molecular Imaging
title_full_unstemmed Current Perspectives on In Vivo Noninvasive Tracking of Extracellular Vesicles with Molecular Imaging
title_short Current Perspectives on In Vivo Noninvasive Tracking of Extracellular Vesicles with Molecular Imaging
title_sort current perspectives on in vivo noninvasive tracking of extracellular vesicles with molecular imaging
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303595/
https://www.ncbi.nlm.nih.gov/pubmed/28246609
http://dx.doi.org/10.1155/2017/9158319
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