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Human Papillomavirus (HPV) virion induced cancer and subfertility, two sides of the same coin
In the natural history of HPV infections, the HPV virions can induce two different pathways, namely the infec- tious virion producing pathway and the clonal transforming pathway. An overview is given of the burden that is associated with HPV infections that can both lead to cervical cancer and/or te...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Universa Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303699/ https://www.ncbi.nlm.nih.gov/pubmed/28210481 |
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author | Depuydt, CE Beert, J Bosmans, E Salembier, G |
author_facet | Depuydt, CE Beert, J Bosmans, E Salembier, G |
author_sort | Depuydt, CE |
collection | PubMed |
description | In the natural history of HPV infections, the HPV virions can induce two different pathways, namely the infec- tious virion producing pathway and the clonal transforming pathway. An overview is given of the burden that is associated with HPV infections that can both lead to cervical cancer and/or temporal subfertility. That HPV infections cause serious global health burden due to HPV-associated cancers is common knowledge, but that it is also responsible for a substantial part of idiopathic subfertility is greatly underestimated. The bulk of the detected HPV DNA whether in men or women is however infectious from origin. Because the dissociation between HPV viruses and HPV virions or infection and disease remains difficult for clinicians as well as for HPV detection, we propose a review of the different effects caused by the two different HPV virion induced pathways, and highlight the mechanisms that are responsible for causing transient subfertility and cancer. |
format | Online Article Text |
id | pubmed-5303699 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Universa Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-53036992017-02-16 Human Papillomavirus (HPV) virion induced cancer and subfertility, two sides of the same coin Depuydt, CE Beert, J Bosmans, E Salembier, G Facts Views Vis Obgyn Review In the natural history of HPV infections, the HPV virions can induce two different pathways, namely the infec- tious virion producing pathway and the clonal transforming pathway. An overview is given of the burden that is associated with HPV infections that can both lead to cervical cancer and/or temporal subfertility. That HPV infections cause serious global health burden due to HPV-associated cancers is common knowledge, but that it is also responsible for a substantial part of idiopathic subfertility is greatly underestimated. The bulk of the detected HPV DNA whether in men or women is however infectious from origin. Because the dissociation between HPV viruses and HPV virions or infection and disease remains difficult for clinicians as well as for HPV detection, we propose a review of the different effects caused by the two different HPV virion induced pathways, and highlight the mechanisms that are responsible for causing transient subfertility and cancer. Universa Press 2016-12 2017-02-12 /pmc/articles/PMC5303699/ /pubmed/28210481 Text en Copyright © 2017 Facts, Views & Vision http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Depuydt, CE Beert, J Bosmans, E Salembier, G Human Papillomavirus (HPV) virion induced cancer and subfertility, two sides of the same coin |
title | Human Papillomavirus (HPV) virion induced cancer and subfertility, two sides of the same coin |
title_full | Human Papillomavirus (HPV) virion induced cancer and subfertility, two sides of the same coin |
title_fullStr | Human Papillomavirus (HPV) virion induced cancer and subfertility, two sides of the same coin |
title_full_unstemmed | Human Papillomavirus (HPV) virion induced cancer and subfertility, two sides of the same coin |
title_short | Human Papillomavirus (HPV) virion induced cancer and subfertility, two sides of the same coin |
title_sort | human papillomavirus (hpv) virion induced cancer and subfertility, two sides of the same coin |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303699/ https://www.ncbi.nlm.nih.gov/pubmed/28210481 |
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