First Report of CD4 Lymphopenia and Defective Neutrophil Functions in a Patient with Amebiasis Associated with CMV Reactivation and Severe Bacterial and Fungal Infections

We report the case of a patient with acute necrotizing colitis due to invasive amebiasis associated with CD4 lymphopenia and impaired neutrophil responses. The course of the disease was characterized by CMV reactivation and severe and recurrent bacterial and fungal infections, which might be related...

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Autores principales: Ghrenassia, Etienne, Guihot, Amélie, Dong, Yuan, Robinet, Pauline, Fontaine, Thierry, Lacombe, Karine, Lescot, Thomas, Meyohas, Marie-Caroline, Elbim, Carole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303735/
https://www.ncbi.nlm.nih.gov/pubmed/28243230
http://dx.doi.org/10.3389/fmicb.2017.00203
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author Ghrenassia, Etienne
Guihot, Amélie
Dong, Yuan
Robinet, Pauline
Fontaine, Thierry
Lacombe, Karine
Lescot, Thomas
Meyohas, Marie-Caroline
Elbim, Carole
author_facet Ghrenassia, Etienne
Guihot, Amélie
Dong, Yuan
Robinet, Pauline
Fontaine, Thierry
Lacombe, Karine
Lescot, Thomas
Meyohas, Marie-Caroline
Elbim, Carole
author_sort Ghrenassia, Etienne
collection PubMed
description We report the case of a patient with acute necrotizing colitis due to invasive amebiasis associated with CD4 lymphopenia and impaired neutrophil responses. The course of the disease was characterized by CMV reactivation and severe and recurrent bacterial and fungal infections, which might be related to the decreased CD4 T cell count and the impaired functional capacities of neutrophils, respectively. The clinical outcome was positive with normalization of both CD4 cell count and neutrophil functions.
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spelling pubmed-53037352017-02-27 First Report of CD4 Lymphopenia and Defective Neutrophil Functions in a Patient with Amebiasis Associated with CMV Reactivation and Severe Bacterial and Fungal Infections Ghrenassia, Etienne Guihot, Amélie Dong, Yuan Robinet, Pauline Fontaine, Thierry Lacombe, Karine Lescot, Thomas Meyohas, Marie-Caroline Elbim, Carole Front Microbiol Microbiology We report the case of a patient with acute necrotizing colitis due to invasive amebiasis associated with CD4 lymphopenia and impaired neutrophil responses. The course of the disease was characterized by CMV reactivation and severe and recurrent bacterial and fungal infections, which might be related to the decreased CD4 T cell count and the impaired functional capacities of neutrophils, respectively. The clinical outcome was positive with normalization of both CD4 cell count and neutrophil functions. Frontiers Media S.A. 2017-02-13 /pmc/articles/PMC5303735/ /pubmed/28243230 http://dx.doi.org/10.3389/fmicb.2017.00203 Text en Copyright © 2017 Ghrenassia, Guihot, Dong, Robinet, Fontaine, Lacombe, Lescot, Meyohas and Elbim. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Ghrenassia, Etienne
Guihot, Amélie
Dong, Yuan
Robinet, Pauline
Fontaine, Thierry
Lacombe, Karine
Lescot, Thomas
Meyohas, Marie-Caroline
Elbim, Carole
First Report of CD4 Lymphopenia and Defective Neutrophil Functions in a Patient with Amebiasis Associated with CMV Reactivation and Severe Bacterial and Fungal Infections
title First Report of CD4 Lymphopenia and Defective Neutrophil Functions in a Patient with Amebiasis Associated with CMV Reactivation and Severe Bacterial and Fungal Infections
title_full First Report of CD4 Lymphopenia and Defective Neutrophil Functions in a Patient with Amebiasis Associated with CMV Reactivation and Severe Bacterial and Fungal Infections
title_fullStr First Report of CD4 Lymphopenia and Defective Neutrophil Functions in a Patient with Amebiasis Associated with CMV Reactivation and Severe Bacterial and Fungal Infections
title_full_unstemmed First Report of CD4 Lymphopenia and Defective Neutrophil Functions in a Patient with Amebiasis Associated with CMV Reactivation and Severe Bacterial and Fungal Infections
title_short First Report of CD4 Lymphopenia and Defective Neutrophil Functions in a Patient with Amebiasis Associated with CMV Reactivation and Severe Bacterial and Fungal Infections
title_sort first report of cd4 lymphopenia and defective neutrophil functions in a patient with amebiasis associated with cmv reactivation and severe bacterial and fungal infections
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303735/
https://www.ncbi.nlm.nih.gov/pubmed/28243230
http://dx.doi.org/10.3389/fmicb.2017.00203
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