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Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia
Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,20...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303820/ https://www.ncbi.nlm.nih.gov/pubmed/28165464 http://dx.doi.org/10.1038/ncomms14175 |
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| author | Law, Philip J. Berndt, Sonja I. Speedy, Helen E. Camp, Nicola J. Sava, Georgina P. Skibola, Christine F. Holroyd, Amy Joseph, Vijai Sunter, Nicola J. Nieters, Alexandra Bea, Silvia Monnereau, Alain Martin-Garcia, David Goldin, Lynn R. Clot, Guillem Teras, Lauren R. Quintela, Inés Birmann, Brenda M. Jayne, Sandrine Cozen, Wendy Majid, Aneela Smedby, Karin E. Lan, Qing Dearden, Claire Brooks-Wilson, Angela R. Hall, Andrew G. Purdue, Mark P. Mainou-Fowler, Tryfonia Vajdic, Claire M. Jackson, Graham H. Cocco, Pierluigi Marr, Helen Zhang, Yawei Zheng, Tongzhang Giles, Graham G. Lawrence, Charles Call, Timothy G. Liebow, Mark Melbye, Mads Glimelius, Bengt Mansouri, Larry Glenn, Martha Curtin, Karen Diver, W Ryan Link, Brian K. Conde, Lucia Bracci, Paige M. Holly, Elizabeth A. Jackson, Rebecca D. Tinker, Lesley F. Benavente, Yolanda Boffetta, Paolo Brennan, Paul Maynadie, Marc McKay, James Albanes, Demetrius Weinstein, Stephanie Wang, Zhaoming Caporaso, Neil E. Morton, Lindsay M. Severson, Richard K. Riboli, Elio Vineis, Paolo Vermeulen, Roel C. H. Southey, Melissa C. Milne, Roger L. Clavel, Jacqueline Topka, Sabine Spinelli, John J. Kraft, Peter Ennas, Maria Grazia Summerfield, Geoffrey Ferri, Giovanni M. Harris, Robert J. Miligi, Lucia Pettitt, Andrew R. North, Kari E. Allsup, David J. Fraumeni, Joseph F. Bailey, James R. Offit, Kenneth Pratt, Guy Hjalgrim, Henrik Pepper, Chris Chanock, Stephen J. Fegan, Chris Rosenquist, Richard de Sanjose, Silvia Carracedo, Angel Dyer, Martin J. S. Catovsky, Daniel Campo, Elias Cerhan, James R. Allan, James M. Rothman, Nathanial Houlston, Richard Slager, Susan |
| author_facet | Law, Philip J. Berndt, Sonja I. Speedy, Helen E. Camp, Nicola J. Sava, Georgina P. Skibola, Christine F. Holroyd, Amy Joseph, Vijai Sunter, Nicola J. Nieters, Alexandra Bea, Silvia Monnereau, Alain Martin-Garcia, David Goldin, Lynn R. Clot, Guillem Teras, Lauren R. Quintela, Inés Birmann, Brenda M. Jayne, Sandrine Cozen, Wendy Majid, Aneela Smedby, Karin E. Lan, Qing Dearden, Claire Brooks-Wilson, Angela R. Hall, Andrew G. Purdue, Mark P. Mainou-Fowler, Tryfonia Vajdic, Claire M. Jackson, Graham H. Cocco, Pierluigi Marr, Helen Zhang, Yawei Zheng, Tongzhang Giles, Graham G. Lawrence, Charles Call, Timothy G. Liebow, Mark Melbye, Mads Glimelius, Bengt Mansouri, Larry Glenn, Martha Curtin, Karen Diver, W Ryan Link, Brian K. Conde, Lucia Bracci, Paige M. Holly, Elizabeth A. Jackson, Rebecca D. Tinker, Lesley F. Benavente, Yolanda Boffetta, Paolo Brennan, Paul Maynadie, Marc McKay, James Albanes, Demetrius Weinstein, Stephanie Wang, Zhaoming Caporaso, Neil E. Morton, Lindsay M. Severson, Richard K. Riboli, Elio Vineis, Paolo Vermeulen, Roel C. H. Southey, Melissa C. Milne, Roger L. Clavel, Jacqueline Topka, Sabine Spinelli, John J. Kraft, Peter Ennas, Maria Grazia Summerfield, Geoffrey Ferri, Giovanni M. Harris, Robert J. Miligi, Lucia Pettitt, Andrew R. North, Kari E. Allsup, David J. Fraumeni, Joseph F. Bailey, James R. Offit, Kenneth Pratt, Guy Hjalgrim, Henrik Pepper, Chris Chanock, Stephen J. Fegan, Chris Rosenquist, Richard de Sanjose, Silvia Carracedo, Angel Dyer, Martin J. S. Catovsky, Daniel Campo, Elias Cerhan, James R. Allan, James M. Rothman, Nathanial Houlston, Richard Slager, Susan |
| author_sort | Law, Philip J. |
| collection | PubMed |
| description | Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10(−13)), 1q42.13 (rs41271473, P=1.06 × 10(−10)), 4q24 (rs71597109, P=1.37 × 10(−10)), 4q35.1 (rs57214277, P=3.69 × 10(−8)), 6p21.31 (rs3800461, P=1.97 × 10(−8)), 11q23.2 (rs61904987, P=2.64 × 10(−11)), 18q21.1 (rs1036935, P=3.27 × 10(−8)), 19p13.3 (rs7254272, P=4.67 × 10(−8)) and 22q13.33 (rs140522, P=2.70 × 10(−9)). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response. |
| format | Online Article Text |
| id | pubmed-5303820 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-53038202017-02-27 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia Law, Philip J. Berndt, Sonja I. Speedy, Helen E. Camp, Nicola J. Sava, Georgina P. Skibola, Christine F. Holroyd, Amy Joseph, Vijai Sunter, Nicola J. Nieters, Alexandra Bea, Silvia Monnereau, Alain Martin-Garcia, David Goldin, Lynn R. Clot, Guillem Teras, Lauren R. Quintela, Inés Birmann, Brenda M. Jayne, Sandrine Cozen, Wendy Majid, Aneela Smedby, Karin E. Lan, Qing Dearden, Claire Brooks-Wilson, Angela R. Hall, Andrew G. Purdue, Mark P. Mainou-Fowler, Tryfonia Vajdic, Claire M. Jackson, Graham H. Cocco, Pierluigi Marr, Helen Zhang, Yawei Zheng, Tongzhang Giles, Graham G. Lawrence, Charles Call, Timothy G. Liebow, Mark Melbye, Mads Glimelius, Bengt Mansouri, Larry Glenn, Martha Curtin, Karen Diver, W Ryan Link, Brian K. Conde, Lucia Bracci, Paige M. Holly, Elizabeth A. Jackson, Rebecca D. Tinker, Lesley F. Benavente, Yolanda Boffetta, Paolo Brennan, Paul Maynadie, Marc McKay, James Albanes, Demetrius Weinstein, Stephanie Wang, Zhaoming Caporaso, Neil E. Morton, Lindsay M. Severson, Richard K. Riboli, Elio Vineis, Paolo Vermeulen, Roel C. H. Southey, Melissa C. Milne, Roger L. Clavel, Jacqueline Topka, Sabine Spinelli, John J. Kraft, Peter Ennas, Maria Grazia Summerfield, Geoffrey Ferri, Giovanni M. Harris, Robert J. Miligi, Lucia Pettitt, Andrew R. North, Kari E. Allsup, David J. Fraumeni, Joseph F. Bailey, James R. Offit, Kenneth Pratt, Guy Hjalgrim, Henrik Pepper, Chris Chanock, Stephen J. Fegan, Chris Rosenquist, Richard de Sanjose, Silvia Carracedo, Angel Dyer, Martin J. S. Catovsky, Daniel Campo, Elias Cerhan, James R. Allan, James M. Rothman, Nathanial Houlston, Richard Slager, Susan Nat Commun Article Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10(−13)), 1q42.13 (rs41271473, P=1.06 × 10(−10)), 4q24 (rs71597109, P=1.37 × 10(−10)), 4q35.1 (rs57214277, P=3.69 × 10(−8)), 6p21.31 (rs3800461, P=1.97 × 10(−8)), 11q23.2 (rs61904987, P=2.64 × 10(−11)), 18q21.1 (rs1036935, P=3.27 × 10(−8)), 19p13.3 (rs7254272, P=4.67 × 10(−8)) and 22q13.33 (rs140522, P=2.70 × 10(−9)). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response. Nature Publishing Group 2017-02-06 /pmc/articles/PMC5303820/ /pubmed/28165464 http://dx.doi.org/10.1038/ncomms14175 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Article Law, Philip J. Berndt, Sonja I. Speedy, Helen E. Camp, Nicola J. Sava, Georgina P. Skibola, Christine F. Holroyd, Amy Joseph, Vijai Sunter, Nicola J. Nieters, Alexandra Bea, Silvia Monnereau, Alain Martin-Garcia, David Goldin, Lynn R. Clot, Guillem Teras, Lauren R. Quintela, Inés Birmann, Brenda M. Jayne, Sandrine Cozen, Wendy Majid, Aneela Smedby, Karin E. Lan, Qing Dearden, Claire Brooks-Wilson, Angela R. Hall, Andrew G. Purdue, Mark P. Mainou-Fowler, Tryfonia Vajdic, Claire M. Jackson, Graham H. Cocco, Pierluigi Marr, Helen Zhang, Yawei Zheng, Tongzhang Giles, Graham G. Lawrence, Charles Call, Timothy G. Liebow, Mark Melbye, Mads Glimelius, Bengt Mansouri, Larry Glenn, Martha Curtin, Karen Diver, W Ryan Link, Brian K. Conde, Lucia Bracci, Paige M. Holly, Elizabeth A. Jackson, Rebecca D. Tinker, Lesley F. Benavente, Yolanda Boffetta, Paolo Brennan, Paul Maynadie, Marc McKay, James Albanes, Demetrius Weinstein, Stephanie Wang, Zhaoming Caporaso, Neil E. Morton, Lindsay M. Severson, Richard K. Riboli, Elio Vineis, Paolo Vermeulen, Roel C. H. Southey, Melissa C. Milne, Roger L. Clavel, Jacqueline Topka, Sabine Spinelli, John J. Kraft, Peter Ennas, Maria Grazia Summerfield, Geoffrey Ferri, Giovanni M. Harris, Robert J. Miligi, Lucia Pettitt, Andrew R. North, Kari E. Allsup, David J. Fraumeni, Joseph F. Bailey, James R. Offit, Kenneth Pratt, Guy Hjalgrim, Henrik Pepper, Chris Chanock, Stephen J. Fegan, Chris Rosenquist, Richard de Sanjose, Silvia Carracedo, Angel Dyer, Martin J. S. Catovsky, Daniel Campo, Elias Cerhan, James R. Allan, James M. Rothman, Nathanial Houlston, Richard Slager, Susan Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia |
| title | Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia |
| title_full | Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia |
| title_fullStr | Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia |
| title_full_unstemmed | Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia |
| title_short | Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia |
| title_sort | genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303820/ https://www.ncbi.nlm.nih.gov/pubmed/28165464 http://dx.doi.org/10.1038/ncomms14175 |
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