Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo

Goadsporin (GS) is a member of ribosomally synthesized and post-translationally modified peptides (RiPPs), containing an N-terminal acetyl moiety, six azoles and two dehydroalanines in the peptidic main chain. Although the enzymes involved in GS biosynthesis have been defined, the principle of how t...

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Detalles Bibliográficos
Autores principales: Ozaki, Taro, Yamashita, Kona, Goto, Yuki, Shimomura, Morito, Hayashi, Shohei, Asamizu, Shumpei, Sugai, Yoshinori, Ikeda, Haruo, Suga, Hiroaki, Onaka, Hiroyasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303826/
https://www.ncbi.nlm.nih.gov/pubmed/28165449
http://dx.doi.org/10.1038/ncomms14207

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