FAK signalling controls insulin sensitivity through regulation of adipocyte survival

Focal adhesion kinase (FAK) plays a central role in integrin signalling, which regulates growth and survival of tumours. Here we show that FAK protein levels are increased in adipose tissue of insulin-resistant obese mice and humans. Disruption of adipocyte FAK in mice or in 3T3 L1 cells decreases a...

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Detalles Bibliográficos
Autores principales: Luk, Cynthia T., Shi, Sally Yu, Cai, Erica P., Sivasubramaniyam, Tharini, Krishnamurthy, Mansa, Brunt, Jara J., Schroer, Stephanie A., Winer, Daniel A., Woo, Minna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303880/
https://www.ncbi.nlm.nih.gov/pubmed/28165007
http://dx.doi.org/10.1038/ncomms14360

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