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SR Proteins: Binders, Regulators, and Connectors of RNA
Serine and arginine-rich (SR) proteins are RNA-binding proteins (RBPs) known as constitutive and alternative splicing regulators. As splicing is linked to transcriptional and post-transcriptional steps, SR proteins are implicated in the regulation of multiple aspects of the gene expression program....
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society for Molecular and Cellular Biology
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303883/ https://www.ncbi.nlm.nih.gov/pubmed/28152302 http://dx.doi.org/10.14348/molcells.2017.2319 |
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author | Jeong, Sunjoo |
author_facet | Jeong, Sunjoo |
author_sort | Jeong, Sunjoo |
collection | PubMed |
description | Serine and arginine-rich (SR) proteins are RNA-binding proteins (RBPs) known as constitutive and alternative splicing regulators. As splicing is linked to transcriptional and post-transcriptional steps, SR proteins are implicated in the regulation of multiple aspects of the gene expression program. Recent global analyses of SR-RNA interaction maps have advanced our understanding of SR-regulated gene expression. Diverse SR proteins play partially overlapping but distinct roles in transcription-coupled splicing and mRNA processing in the nucleus. In addition, shuttling SR proteins act as adaptors for mRNA export and as regulators for translation in the cytoplasm. This mini-review will summarize the roles of SR proteins as RNA binders, regulators, and connectors from transcription in the nucleus to translation in the cytoplasm. |
format | Online Article Text |
id | pubmed-5303883 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Korean Society for Molecular and Cellular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-53038832017-02-22 SR Proteins: Binders, Regulators, and Connectors of RNA Jeong, Sunjoo Mol Cells Minireview Serine and arginine-rich (SR) proteins are RNA-binding proteins (RBPs) known as constitutive and alternative splicing regulators. As splicing is linked to transcriptional and post-transcriptional steps, SR proteins are implicated in the regulation of multiple aspects of the gene expression program. Recent global analyses of SR-RNA interaction maps have advanced our understanding of SR-regulated gene expression. Diverse SR proteins play partially overlapping but distinct roles in transcription-coupled splicing and mRNA processing in the nucleus. In addition, shuttling SR proteins act as adaptors for mRNA export and as regulators for translation in the cytoplasm. This mini-review will summarize the roles of SR proteins as RNA binders, regulators, and connectors from transcription in the nucleus to translation in the cytoplasm. Korean Society for Molecular and Cellular Biology 2017-01-31 2017-01-26 /pmc/articles/PMC5303883/ /pubmed/28152302 http://dx.doi.org/10.14348/molcells.2017.2319 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/. |
spellingShingle | Minireview Jeong, Sunjoo SR Proteins: Binders, Regulators, and Connectors of RNA |
title | SR Proteins: Binders, Regulators, and Connectors of RNA |
title_full | SR Proteins: Binders, Regulators, and Connectors of RNA |
title_fullStr | SR Proteins: Binders, Regulators, and Connectors of RNA |
title_full_unstemmed | SR Proteins: Binders, Regulators, and Connectors of RNA |
title_short | SR Proteins: Binders, Regulators, and Connectors of RNA |
title_sort | sr proteins: binders, regulators, and connectors of rna |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303883/ https://www.ncbi.nlm.nih.gov/pubmed/28152302 http://dx.doi.org/10.14348/molcells.2017.2319 |
work_keys_str_mv | AT jeongsunjoo srproteinsbindersregulatorsandconnectorsofrna |