PKCθ-Mediated PDK1 Phosphorylation Enhances T Cell Activation by Increasing PDK1 Stability

PDK1 is essential for T cell receptor (TCR)-mediated activation of NF-κB, and PDK1-induced phosphorylation of PKCθ is important for TCR-induced NF-κB activation. However, inverse regulation of PDK1 by PKCθ during T cell activation has not been investigated. In this study, we found that PKCθ is invol...

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Detalles Bibliográficos
Autores principales: Kang, Jung-Ah, Choi, Hyunwoo, Yang, Taewoo, Cho, Steve K., Park, Zee-Yong, Park, Sung-Gyoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303887/
https://www.ncbi.nlm.nih.gov/pubmed/28152304
http://dx.doi.org/10.14348/molcells.2017.2236

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