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Development of a Reporter System for In Vivo Monitoring of γ-Secretase Activity in Drosophila

The γ-secretase complex represents an evolutionarily conserved family of transmembrane aspartyl proteases that cleave numerous type-I membrane proteins, including the β-amyloid precursor protein (APP) and the receptor Notch. All known rare mutations in APP and the γ-secretase catalytic component, pr...

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Detalles Bibliográficos
Autores principales:	Hong, Young Gi, Roh, Seyun, Paik, Donggi, Jeong, Sangyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Molecular and Cellular Biology 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303891/ https://www.ncbi.nlm.nih.gov/pubmed/28152299 http://dx.doi.org/10.14348/molcells.2017.2294

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