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Cu(II)(atsm) improves the neurological phenotype and survival of SOD1(G93A) mice and selectively increases enzymatically active SOD1 in the spinal cord

Ubiquitous expression of mutant Cu/Zn-superoxide dismutase (SOD1) selectively affects motor neurons in the central nervous system (CNS), causing the adult-onset degenerative disease amyotrophic lateral sclerosis (ALS). The CNS-specific impact of ubiquitous mutant SOD1 expression is recapitulated in...

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Detalles Bibliográficos
Autores principales: Hilton, James B., Mercer, Stephen W., Lim, Nastasia K. H., Faux, Noel G., Buncic, Gojko, Beckman, Joseph S., Roberts, Blaine R., Donnelly, Paul S., White, Anthony R., Crouch, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304223/
https://www.ncbi.nlm.nih.gov/pubmed/28205575
http://dx.doi.org/10.1038/srep42292

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