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The active metabolite of leflunomide, A77 1726, attenuates inflammatory arthritis in mice with spontaneous arthritis via induction of heme oxygenase-1

BACKGROUND: Leflunomide is a low-molecular-weight compound that is widely used in the treatment of rheumatoid arthritis. Although leflunomide is thought to act through the inhibition of the de novo pyrimidine synthesis, the molecular mechanism of the drug remains largely unknown. We investigated the...

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Detalles Bibliográficos
Autores principales:	Moon, Su-Jin, Kim, Eun-Kyung, Jhun, Joo Yeon, Lee, Hee Jin, Lee, Weon Sun, Park, Sang-Hi, Cho, Mi-La, Min, Jun-Ki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304395/ https://www.ncbi.nlm.nih.gov/pubmed/28193225 http://dx.doi.org/10.1186/s12967-017-1131-x

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