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Acute plasma tau relates to prolonged return to play after concussion
OBJECTIVE: To determine whether tau changes after sport-related concussion (SRC) relate to return to play (RTP). METHODS: Collegiate athletes underwent preseason plasma sampling and cognitive testing and were followed. After a SRC (n = 46), athletes and controls (n = 37) had sampling at 6 hours, and...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Lippincott Williams & Wilkins
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304458/ https://www.ncbi.nlm.nih.gov/pubmed/28062722 http://dx.doi.org/10.1212/WNL.0000000000003587 |
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author | Gill, Jessica Merchant-Borna, Kian Jeromin, Andreas Livingston, Whitney Bazarian, Jeffrey |
author_facet | Gill, Jessica Merchant-Borna, Kian Jeromin, Andreas Livingston, Whitney Bazarian, Jeffrey |
author_sort | Gill, Jessica |
collection | PubMed |
description | OBJECTIVE: To determine whether tau changes after sport-related concussion (SRC) relate to return to play (RTP). METHODS: Collegiate athletes underwent preseason plasma sampling and cognitive testing and were followed. After a SRC (n = 46), athletes and controls (n = 37) had sampling at 6 hours, and at 24 hours, 72 hours, and 7 days after SRC. A sample of 21 nonathlete controls were compared at baseline. SRC athletes were grouped by long (>10 days, n = 23) and short (≤10 days, n = 18) RTP. Total tau was measured using an ultrasensitive immunoassay. RESULTS: Both SRC and athlete controls had significantly higher mean tau at baseline compared to nonathlete healthy controls (F(101,3) = 19.644, p < 0.01). Compared to SRC athletes with short RTP, those with long RTP had higher tau concentrations overall, after controlling for sex (F(39,1) = 3.59, p = 0.022), compared to long RTP athletes, at 6 (p < 0.01), 24 (p < 0.01), and 72 hours (p = 0.02). Receiver operator characteristic analyses showed that higher plasma tau 6 hours post-SRC was a significant predictor of RTP >10 days (area under the curve 0.81; 95% confidence interval 0.62–0.97, p = 0.01). CONCLUSIONS: Elevated plasma tau concentration within 6 hours following a SRC was related to having a prolonged RTP, suggesting that tau levels may help inform RTP. |
format | Online Article Text |
id | pubmed-5304458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-53044582017-02-22 Acute plasma tau relates to prolonged return to play after concussion Gill, Jessica Merchant-Borna, Kian Jeromin, Andreas Livingston, Whitney Bazarian, Jeffrey Neurology Article OBJECTIVE: To determine whether tau changes after sport-related concussion (SRC) relate to return to play (RTP). METHODS: Collegiate athletes underwent preseason plasma sampling and cognitive testing and were followed. After a SRC (n = 46), athletes and controls (n = 37) had sampling at 6 hours, and at 24 hours, 72 hours, and 7 days after SRC. A sample of 21 nonathlete controls were compared at baseline. SRC athletes were grouped by long (>10 days, n = 23) and short (≤10 days, n = 18) RTP. Total tau was measured using an ultrasensitive immunoassay. RESULTS: Both SRC and athlete controls had significantly higher mean tau at baseline compared to nonathlete healthy controls (F(101,3) = 19.644, p < 0.01). Compared to SRC athletes with short RTP, those with long RTP had higher tau concentrations overall, after controlling for sex (F(39,1) = 3.59, p = 0.022), compared to long RTP athletes, at 6 (p < 0.01), 24 (p < 0.01), and 72 hours (p = 0.02). Receiver operator characteristic analyses showed that higher plasma tau 6 hours post-SRC was a significant predictor of RTP >10 days (area under the curve 0.81; 95% confidence interval 0.62–0.97, p = 0.01). CONCLUSIONS: Elevated plasma tau concentration within 6 hours following a SRC was related to having a prolonged RTP, suggesting that tau levels may help inform RTP. Lippincott Williams & Wilkins 2017-02-07 /pmc/articles/PMC5304458/ /pubmed/28062722 http://dx.doi.org/10.1212/WNL.0000000000003587 Text en Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Article Gill, Jessica Merchant-Borna, Kian Jeromin, Andreas Livingston, Whitney Bazarian, Jeffrey Acute plasma tau relates to prolonged return to play after concussion |
title | Acute plasma tau relates to prolonged return to play after concussion |
title_full | Acute plasma tau relates to prolonged return to play after concussion |
title_fullStr | Acute plasma tau relates to prolonged return to play after concussion |
title_full_unstemmed | Acute plasma tau relates to prolonged return to play after concussion |
title_short | Acute plasma tau relates to prolonged return to play after concussion |
title_sort | acute plasma tau relates to prolonged return to play after concussion |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304458/ https://www.ncbi.nlm.nih.gov/pubmed/28062722 http://dx.doi.org/10.1212/WNL.0000000000003587 |
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