Down syndrome as risk factor for respiratory syncytial virus hospitalization: A prospective multicenter epidemiological study

BACKGROUND: Respiratory syncytial virus (RSV) infection in childhood, particularly in premature infants, is associated with significant morbidity and mortality. OBJECTIVES: To compare the hospitalization rates due to RSV infection and severity of disease between infants with and without Down syndrom...

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Autores principales: Sánchez‐Luna, Manuel, Medrano, Constancio, Lirio, Julián, Suazo, José Antonio Hurtado, Peña, Manuela, López, Eduardo Narbona, Fernández, José Uberos, Jover, Enrique Blanca, Perales, Antonio Bonillo, Delgado, Javier Díes, Montes, Mª Ángeles Ortega, de la Cruz Moreno, Jesús, Tardío, Joaquín Ortiz, Esteban, Mª Victoria, Millán, Leticia, Peracaula, Carlos Salido, Trujillo, Gloria María Quesada, Pajares, José David Martínez, López, Simón Pedro Lubián, Aranda, Salvador Ariza, Faci, Mª Purificación Ventura, Guillén, Sofía Valle, Lozano, Olga Bueno, Gracia, Segundo Rite, Cabezas, Miguel Ángel García, Ramírez, Natalia Bejarano, Machado, Mª Carmen Fresneda, Gutiérrez, Andrés Martínez, Rodríguez, Sara Rellán, Temprano, Marianela Marcos, Vicente, Elena Ortega, Malfaz, Fernando Centeno, Martín, Laura San Feliciano, Escalero, Ana Remesal, Zaballos, Francisca Benito, Closa‐Monasterolo, Ricardo, Salvadó, Silvia Franch, Sanz, Israel Fernando Anquela, Castells, Joaquim Bosch, Fagundo, Alberto Trujillo, Malfaz, Emma Ametller, Fernández, Mario José Sánchez, Mir, Eduard Solé, Lletget, Wilfredo Coroleu, Carrera, Ignacio Arroyo, Perianes, María Taboada, Pico, Mª Luz Couce, Seara, María José Fernández, del Prado, Mª Yolanda Ruiz, Olive, Mª Luisa Poch, Maderuelo, Elena, Zeballos, Susana, Orozco, Ana Leal, Serrano, Cristina Ruíz, Omeñaca, Félix, Palomino, Esperanza Escribano, Guereta, Luis García, Jiménez, Vicente Bosch, Sánchez, José Diego Gutiérrez, Pidre, Manuel Cidrás, Sánchez, Natividad Viguria, Orayen, Concepción Goñi, Unceta‐Barrenechea, Ana Aguirre, Legorburu, Alberto Pérez, Ortuño, Mª José Palao, Crespo, Maribel Giner, Muñoz, Ángel González, Macián, Mª Isabel Izquierdo, Zafra, Rafael Gómez, Colunga, Juan Mayordomo, Zapico, Bárbara Montes, Varas, María Rosón, Matilla, María Mora, Herroz, Ignacio Oulego, Pereira, Mª Teresa Prada, Consuegra, Miguel Ángel Arias, Vilella, Laura Castells, Cazcarra, Jesús Antonio Mairal, Ruiz, Silvia Yévenes, de Terrassa, Consorci Sanitàri, Díez, Isabel Sáez, Reymundo, Mercedes García, López, Esther Piñán, Sarabia, Javier Fernández, Cáceres, Sofía Hernández, Lois, Mª Gloria López, Olivas, Cristina, Martin, Mª José Rivero, de las Heras Ibarra, Susana, Cuadrado, Mercedes, Amador, Jose Tomás Ramos, Martin, Sara Guillén, Díaz, Alfonso Cañete, Corvino, Julia Sopeña, –Puelles, Francisco Javier González‐Valcárcel Sánchez, Sirera, Jose Cambra, García, Begoña Pérez, Candel, Maria Isabel Jiménez, Calvo, Elisa Cueto, Guardia, Leonor, Casero, Julián Lirio, Galiana, Gemma Ginovart, Bernal, Esther López, de León, Lorenzo Sánchez, Ferrandez, Maria Jesus, Quiles, Jose Luis, de Elche, H., Rimblas, Maria, Capaces, Susana Larrosa, Joan de Reus, H. San
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304568/
https://www.ncbi.nlm.nih.gov/pubmed/27611835
http://dx.doi.org/10.1111/irv.12431
Descripción
Sumario:BACKGROUND: Respiratory syncytial virus (RSV) infection in childhood, particularly in premature infants, is associated with significant morbidity and mortality. OBJECTIVES: To compare the hospitalization rates due to RSV infection and severity of disease between infants with and without Down syndrome (DS) born at term and without other associated risk factors for severe RSV infection. PATIENTS/METHODS: In a prospective multicentre epidemiological study, 93 infants were included in the DS cohort and 68 matched by sex and data of birth (±1 week) and were followed up to 1 year of age and during a complete RSV season. RESULTS: The hospitalization rate for all acute respiratory infection was significantly higher in the DS cohort than in the non‐DS cohort (44.1% vs 7.7%, P<.0001). Hospitalizations due to RSV were significantly more frequent in the DH cohort than in the non‐DS cohort (9.7% vs 1.5%, P=.03). RSV prophylaxis was recorded in 33 (35.5%) infants with DS. The rate of hospitalization according to presence or absence of RSV immunoprophylaxis was 3.0% vs 15%, respectively. CONCLUSIONS: Infants with DS showed a higher rate of hospitalization due to acute lower respiratory tract infection and RSV infection compared to non‐DS infants. Including DS infants in recommendations for immunoprophylaxis of RSV disease should be considered.

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