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Rafts, Nanoparticles and Neural Disease
This review examines the role of membrane rafts in neural disease as a rationale for drug targeting utilizing lipid-based nanoparticles. The article begins with an overview of methodological issues involving the existence, sizes, and lifetimes of rafts, and then examines raft function in the etiolog...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304588/ https://www.ncbi.nlm.nih.gov/pubmed/28348305 http://dx.doi.org/10.3390/nano2030217 |
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author | Gulati, Vishal Wallace, Ron |
author_facet | Gulati, Vishal Wallace, Ron |
author_sort | Gulati, Vishal |
collection | PubMed |
description | This review examines the role of membrane rafts in neural disease as a rationale for drug targeting utilizing lipid-based nanoparticles. The article begins with an overview of methodological issues involving the existence, sizes, and lifetimes of rafts, and then examines raft function in the etiologies of three major neural diseases—epilepsy, Parkinson’s disease, and Alzheimer’s disease—selected as promising candidates for raft-based therapeutics. Raft-targeting drug delivery systems involving liposomes and solid lipid nanoparticles are then examined in detail. |
format | Online Article Text |
id | pubmed-5304588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-53045882017-03-21 Rafts, Nanoparticles and Neural Disease Gulati, Vishal Wallace, Ron Nanomaterials (Basel) Review This review examines the role of membrane rafts in neural disease as a rationale for drug targeting utilizing lipid-based nanoparticles. The article begins with an overview of methodological issues involving the existence, sizes, and lifetimes of rafts, and then examines raft function in the etiologies of three major neural diseases—epilepsy, Parkinson’s disease, and Alzheimer’s disease—selected as promising candidates for raft-based therapeutics. Raft-targeting drug delivery systems involving liposomes and solid lipid nanoparticles are then examined in detail. MDPI 2012-08-06 /pmc/articles/PMC5304588/ /pubmed/28348305 http://dx.doi.org/10.3390/nano2030217 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Gulati, Vishal Wallace, Ron Rafts, Nanoparticles and Neural Disease |
title | Rafts, Nanoparticles and Neural Disease |
title_full | Rafts, Nanoparticles and Neural Disease |
title_fullStr | Rafts, Nanoparticles and Neural Disease |
title_full_unstemmed | Rafts, Nanoparticles and Neural Disease |
title_short | Rafts, Nanoparticles and Neural Disease |
title_sort | rafts, nanoparticles and neural disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304588/ https://www.ncbi.nlm.nih.gov/pubmed/28348305 http://dx.doi.org/10.3390/nano2030217 |
work_keys_str_mv | AT gulativishal raftsnanoparticlesandneuraldisease AT wallaceron raftsnanoparticlesandneuraldisease |