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Rafts, Nanoparticles and Neural Disease

This review examines the role of membrane rafts in neural disease as a rationale for drug targeting utilizing lipid-based nanoparticles. The article begins with an overview of methodological issues involving the existence, sizes, and lifetimes of rafts, and then examines raft function in the etiolog...

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Detalles Bibliográficos
Autores principales: Gulati, Vishal, Wallace, Ron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304588/
https://www.ncbi.nlm.nih.gov/pubmed/28348305
http://dx.doi.org/10.3390/nano2030217
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author Gulati, Vishal
Wallace, Ron
author_facet Gulati, Vishal
Wallace, Ron
author_sort Gulati, Vishal
collection PubMed
description This review examines the role of membrane rafts in neural disease as a rationale for drug targeting utilizing lipid-based nanoparticles. The article begins with an overview of methodological issues involving the existence, sizes, and lifetimes of rafts, and then examines raft function in the etiologies of three major neural diseases—epilepsy, Parkinson’s disease, and Alzheimer’s disease—selected as promising candidates for raft-based therapeutics. Raft-targeting drug delivery systems involving liposomes and solid lipid nanoparticles are then examined in detail.
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spelling pubmed-53045882017-03-21 Rafts, Nanoparticles and Neural Disease Gulati, Vishal Wallace, Ron Nanomaterials (Basel) Review This review examines the role of membrane rafts in neural disease as a rationale for drug targeting utilizing lipid-based nanoparticles. The article begins with an overview of methodological issues involving the existence, sizes, and lifetimes of rafts, and then examines raft function in the etiologies of three major neural diseases—epilepsy, Parkinson’s disease, and Alzheimer’s disease—selected as promising candidates for raft-based therapeutics. Raft-targeting drug delivery systems involving liposomes and solid lipid nanoparticles are then examined in detail. MDPI 2012-08-06 /pmc/articles/PMC5304588/ /pubmed/28348305 http://dx.doi.org/10.3390/nano2030217 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Gulati, Vishal
Wallace, Ron
Rafts, Nanoparticles and Neural Disease
title Rafts, Nanoparticles and Neural Disease
title_full Rafts, Nanoparticles and Neural Disease
title_fullStr Rafts, Nanoparticles and Neural Disease
title_full_unstemmed Rafts, Nanoparticles and Neural Disease
title_short Rafts, Nanoparticles and Neural Disease
title_sort rafts, nanoparticles and neural disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304588/
https://www.ncbi.nlm.nih.gov/pubmed/28348305
http://dx.doi.org/10.3390/nano2030217
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