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Impact of Carbon Nano-Onions on Hydra vulgaris as a Model Organism for Nanoecotoxicology

The toxicological effects of pristine and chemically modified carbon nano-onions (CNOs) on the development of the freshwater polyp Hydra vulgaris were investigated in order to elucidate the ecotoxicological effects of CNOs. Chemical modifications of the CNOs were accomplished by surface functionaliz...

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Autores principales: Marchesano, Valentina, Ambrosone, Alfredo, Bartelmess, Juergen, Strisciante, Federica, Tino, Angela, Echegoyen, Luis, Tortiglione, Claudia, Giordani, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304644/
https://www.ncbi.nlm.nih.gov/pubmed/28347067
http://dx.doi.org/10.3390/nano5031331
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author Marchesano, Valentina
Ambrosone, Alfredo
Bartelmess, Juergen
Strisciante, Federica
Tino, Angela
Echegoyen, Luis
Tortiglione, Claudia
Giordani, Silvia
author_facet Marchesano, Valentina
Ambrosone, Alfredo
Bartelmess, Juergen
Strisciante, Federica
Tino, Angela
Echegoyen, Luis
Tortiglione, Claudia
Giordani, Silvia
author_sort Marchesano, Valentina
collection PubMed
description The toxicological effects of pristine and chemically modified carbon nano-onions (CNOs) on the development of the freshwater polyp Hydra vulgaris were investigated in order to elucidate the ecotoxicological effects of CNOs. Chemical modifications of the CNOs were accomplished by surface functionalization with benzoic acid, pyridine and pyridinium moieties. thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FT-IR) and Raman spectroscopy confirmed the covalent surface functionalization of CNOs. Hydra specimens were exposed to the carbon nanomaterials by prolonged incubation within their medium. Uptake was monitored by optical microscopy, and the toxicological effects of the CNOs on Hydra behavior, morphology, as well as the long-term effects on the development and reproductive capability were examined. The obtained data revealed the absence of adverse effects of CNOs (in the range 0.05–0.1 mg/L) in vivo at the whole animal level. Together with previously performed in vitro toxicological analyses, our findings indicate the biosafety of CNOs and the feasibility of employing them as materials for biomedical applications.
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spelling pubmed-53046442017-03-21 Impact of Carbon Nano-Onions on Hydra vulgaris as a Model Organism for Nanoecotoxicology Marchesano, Valentina Ambrosone, Alfredo Bartelmess, Juergen Strisciante, Federica Tino, Angela Echegoyen, Luis Tortiglione, Claudia Giordani, Silvia Nanomaterials (Basel) Article The toxicological effects of pristine and chemically modified carbon nano-onions (CNOs) on the development of the freshwater polyp Hydra vulgaris were investigated in order to elucidate the ecotoxicological effects of CNOs. Chemical modifications of the CNOs were accomplished by surface functionalization with benzoic acid, pyridine and pyridinium moieties. thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FT-IR) and Raman spectroscopy confirmed the covalent surface functionalization of CNOs. Hydra specimens were exposed to the carbon nanomaterials by prolonged incubation within their medium. Uptake was monitored by optical microscopy, and the toxicological effects of the CNOs on Hydra behavior, morphology, as well as the long-term effects on the development and reproductive capability were examined. The obtained data revealed the absence of adverse effects of CNOs (in the range 0.05–0.1 mg/L) in vivo at the whole animal level. Together with previously performed in vitro toxicological analyses, our findings indicate the biosafety of CNOs and the feasibility of employing them as materials for biomedical applications. MDPI 2015-08-13 /pmc/articles/PMC5304644/ /pubmed/28347067 http://dx.doi.org/10.3390/nano5031331 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Marchesano, Valentina
Ambrosone, Alfredo
Bartelmess, Juergen
Strisciante, Federica
Tino, Angela
Echegoyen, Luis
Tortiglione, Claudia
Giordani, Silvia
Impact of Carbon Nano-Onions on Hydra vulgaris as a Model Organism for Nanoecotoxicology
title Impact of Carbon Nano-Onions on Hydra vulgaris as a Model Organism for Nanoecotoxicology
title_full Impact of Carbon Nano-Onions on Hydra vulgaris as a Model Organism for Nanoecotoxicology
title_fullStr Impact of Carbon Nano-Onions on Hydra vulgaris as a Model Organism for Nanoecotoxicology
title_full_unstemmed Impact of Carbon Nano-Onions on Hydra vulgaris as a Model Organism for Nanoecotoxicology
title_short Impact of Carbon Nano-Onions on Hydra vulgaris as a Model Organism for Nanoecotoxicology
title_sort impact of carbon nano-onions on hydra vulgaris as a model organism for nanoecotoxicology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304644/
https://www.ncbi.nlm.nih.gov/pubmed/28347067
http://dx.doi.org/10.3390/nano5031331
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