Pharmaceutical polymorph control in a drug-mimetic supramolecular gel

We report the synthesis of a bis(urea) gelator designed to specifically mimic the chemical structure of the highly polymorphic drug substance ROY. Crystallization of ROY from toluene gels of this gelator results in the formation of the metastable red form instead of the thermodynamic yellow polymorp...

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Detalles Bibliográficos
Autores principales: Foster, Jonathan A., Damodaran, Krishna K., Maurin, Antoine, Day, Graeme M., Thompson, Hugh P. G., Cameron, Gary J., Bernal, Jenifer Cuesta, Steed, Jonathan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304659/
https://www.ncbi.nlm.nih.gov/pubmed/28451150
http://dx.doi.org/10.1039/c6sc04126d

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