Site-selective Suzuki–Miyaura coupling of heteroaryl halides – understanding the trends for pharmaceutically important classes

Suzuki–Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer's global chemistry RKB and CAS Scifinder® databases, the factors that determine the site-selectivity of these reactio...

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Autores principales: Almond-Thynne, Joshua, Blakemore, David C., Pryde, David C., Spivey, Alan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304707/
https://www.ncbi.nlm.nih.gov/pubmed/28451148
http://dx.doi.org/10.1039/c6sc02118b
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author Almond-Thynne, Joshua
Blakemore, David C.
Pryde, David C.
Spivey, Alan C.
author_facet Almond-Thynne, Joshua
Blakemore, David C.
Pryde, David C.
Spivey, Alan C.
author_sort Almond-Thynne, Joshua
collection PubMed
description Suzuki–Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer's global chemistry RKB and CAS Scifinder® databases, the factors that determine the site-selectivity of these reactions are discussed with a view to rationalising the trends found.
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spelling pubmed-53047072017-04-27 Site-selective Suzuki–Miyaura coupling of heteroaryl halides – understanding the trends for pharmaceutically important classes Almond-Thynne, Joshua Blakemore, David C. Pryde, David C. Spivey, Alan C. Chem Sci Chemistry Suzuki–Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer's global chemistry RKB and CAS Scifinder® databases, the factors that determine the site-selectivity of these reactions are discussed with a view to rationalising the trends found. Royal Society of Chemistry 2017-01-01 2016-08-09 /pmc/articles/PMC5304707/ /pubmed/28451148 http://dx.doi.org/10.1039/c6sc02118b Text en This journal is © The Royal Society of Chemistry 2016 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Almond-Thynne, Joshua
Blakemore, David C.
Pryde, David C.
Spivey, Alan C.
Site-selective Suzuki–Miyaura coupling of heteroaryl halides – understanding the trends for pharmaceutically important classes
title Site-selective Suzuki–Miyaura coupling of heteroaryl halides – understanding the trends for pharmaceutically important classes
title_full Site-selective Suzuki–Miyaura coupling of heteroaryl halides – understanding the trends for pharmaceutically important classes
title_fullStr Site-selective Suzuki–Miyaura coupling of heteroaryl halides – understanding the trends for pharmaceutically important classes
title_full_unstemmed Site-selective Suzuki–Miyaura coupling of heteroaryl halides – understanding the trends for pharmaceutically important classes
title_short Site-selective Suzuki–Miyaura coupling of heteroaryl halides – understanding the trends for pharmaceutically important classes
title_sort site-selective suzuki–miyaura coupling of heteroaryl halides – understanding the trends for pharmaceutically important classes
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304707/
https://www.ncbi.nlm.nih.gov/pubmed/28451148
http://dx.doi.org/10.1039/c6sc02118b
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