Cargando…

Bile salt receptor TGR5 is highly expressed in esophageal adenocarcinoma and precancerous lesions with significantly worse overall survival and gender differences

Bile acid reflux in the esophagus plays an important role in the carcinogenesis of esophageal adenocarcinoma (EAC). The G-protein coupled bile acid receptor (TGR5) has been associated with the development of gastrointestinal cancer. However, little is known regarding the role of TGR5 in esophageal c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pang, Chunhong, LaLonde, Amy, Godfrey, Tony E, Que, Jianwen, Sun, Jun, Wu, Tong Tong, Zhou, Zhongren
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304980/ https://www.ncbi.nlm.nih.gov/pubmed/28223834 http://dx.doi.org/10.2147/CEG.S117842

Ejemplares similares

High expression of Claudin-2 in esophageal carcinoma and precancerous lesions is significantly associated with the bile salt receptors VDR and TGR5
por: Abu-Farsakh, Sohaib, et al.
Publicado: (2017)

MCM4 and MCM7, potential novel proliferation markers, significantly correlated with Ki-67, Bmi1, and cyclin E expression in esophageal adenocarcinoma, squamous cell carcinoma, and precancerous lesions(,)
por: Choy, Bonnie, et al.
Publicado: (2016)

Central anorexigenic actions of bile acids are mediated by TGR5
por: Perino, Alessia, et al.
Publicado: (2021)

Circulating Bile Acids in Liver Failure Activate TGR5 and Induce Monocyte Dysfunction
por: Leonhardt, Julia, et al.
Publicado: (2021)

Multigenerational impacts of bile exposure are mediated by TGR5 signaling pathways
por: Baptissart, Marine, et al.
Publicado: (2018)

The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe?
por: Qi, Youchao, et al.
Publicado: (2022)

Bile acid receptor TGR5, NADPH Oxidase NOX5-S and CREB Mediate Bile Acid-Induced DNA Damage In Barrett’s Esophageal Adenocarcinoma Cells
por: Li, Dan, et al.
Publicado: (2016)

Mutational Characterization of the Bile Acid Receptor TGR5 in Primary Sclerosing Cholangitis
por: Hov, Johannes R., et al.
Publicado: (2010)

Cyclin E involved in early stage carcinogenesis of esophageal adenocarcinoma by SNP DNA microarray and immunohistochemical studies
por: Zhou, Zhongren, et al.
Publicado: (2014)

TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload
por: Bidault-Jourdainne, Valeska, et al.
Publicado: (2020)

Role of the bile acid receptor TGR5 (Gpbar-1) in liver damage and regeneration
por: Keitel, Verena, et al.
Publicado: (2014)

Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR
por: Jadhav, Kavita, et al.
Publicado: (2018)

Discovery, optimization, and evaluation of non-bile acid FXR/TGR5 dual agonists
por: Miyata, Sachiho, et al.
Publicado: (2021)

Hepatic Bile Acid Reuptake in the Rat Depends on Bile Acid Conjugation but Not on Agonistic Properties towards FXR and TGR5
por: Trammell, Samuel A. J., et al.
Publicado: (2020)

The bile acid membrane receptor TGR5: a novel pharmacological target in metabolic syndrome
por: Stepanov, Vanesa, et al.
Publicado: (2012)

Parenchymal Cell Damage and Bile Duct Activity in the Precancerous Liver
por: Sutton, P. M.
Publicado: (1962)

GPBAR1/TGR5 Mediates Bile Acid-Induced Cytokine Expression in Murine Kupffer Cells
por: Lou, Guiyu, et al.
Publicado: (2014)

Membrane bile acid receptor TGR5 predicts good prognosis in ampullary adenocarcinoma patients with hyperbilirubinemia
por: Chen, Min-Chan, et al.
Publicado: (2016)

Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein
por: Chen, Geng, et al.
Publicado: (2020)

Activation of the bile acid receptors TGR5 and FXR in the spinal dorsal horn alleviates neuropathic pain
por: Wu, Yuning, et al.
Publicado: (2023)

Allspice and Clove As Source of Triterpene Acids Activating the G Protein-Coupled Bile Acid Receptor TGR5
por: Ladurner, Angela, et al.
Publicado: (2017)

Sarcopenia Induced by Chronic Liver Disease in Mice Requires the Expression of the Bile Acids Membrane Receptor TGR5
por: Abrigo, Johanna, et al.
Publicado: (2020)

Taurochenodeoxycholic Acid Increases cAMP Content via Specially Interacting with Bile Acid Receptor TGR5
por: Qi, Youchao, et al.
Publicado: (2021)

Evaluation of G-Protein-Coupled Bile Acid Receptor 1 (TGR5) Levels in Intrahepatic Cholestasis of Pregnancy
por: Irak, Kader, et al.
Publicado: (2021)

The Association between Salt and Potential Mediators of the Gastric Precancerous Process
por: Thapa, Susan, et al.
Publicado: (2019)

Characterization of the Oral and Esophageal Microbiota in Esophageal Precancerous Lesions and Squamous Cell Carcinoma
por: Li, Zhengqi, et al.
Publicado: (2021)

Spatial transcriptomics analysis of esophageal squamous precancerous lesions and their progression to esophageal cancer
por: Liu, Xuejiao, et al.
Publicado: (2023)

The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis
por: Cipriani, Sabrina, et al.
Publicado: (2011)

Identification of miR-26a as a Target Gene of Bile Acid Receptor GPBAR-1/TGR5
por: Chen, Xiaosong, et al.
Publicado: (2015)

TGR5-HNF4α axis contributes to bile acid-induced gastric intestinal metaplasia markers expression
por: Ni, Zhen, et al.
Publicado: (2020)

The G Protein-Coupled Bile Acid Receptor TGR5 (Gpbar1) Modulates Endothelin-1 Signaling in Liver
por: Klindt, Caroline, et al.
Publicado: (2019)

Bile Acids Induce Neurite Outgrowth in Nsc-34 Cells via TGR5 and a Distinct Transcriptional Profile
por: Ackerman, Hayley D., et al.
Publicado: (2023)

COX-2 strengthens the effects of acid and bile salts on human esophageal cells and Barrett esophageal cells
por: Jiangang, Shen, et al.
Publicado: (2022)

Association between Dietary Salt Intake and Progression in the Gastric Precancerous Process
por: Thapa, Susan, et al.
Publicado: (2019)

ANO1 protein as a potential biomarker for esophageal cancer prognosis and precancerous lesion development prediction
por: Shang, Li, et al.
Publicado: (2016)

Descubra smalltalk
por: LaLonde, Wilf 1947-
Publicado: (1997)

Correction: The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis
por: Cipriani, Sabrina, et al.
Publicado: (2013)

The Gut Microbiota as a Therapeutic Target in IBD and Metabolic Disease: A Role for the Bile Acid Receptors FXR and TGR5
por: Baars, Annemarie, et al.
Publicado: (2015)

Bile acids and their respective conjugates elicit different responses in neonatal cardiomyocytes: role of Gi protein, muscarinic receptors and TGR5
por: Ibrahim, Effendi, et al.
Publicado: (2018)

Blueberry Extract Improves Obesity through Regulation of the Gut Microbiota and Bile Acids via Pathways Involving FXR and TGR5
por: Guo, Jielong, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_edu5jibfijbevaqs64rie8ft3t