Lickometry: A novel and sensitive method for assessing functional deficits in rats after stroke

The need for sensitive, easy to administer assessments of long-term functional deficits is crucial in pre-clinical stroke research. In the present study, we introduce lickometry (lick microstructure analysis) as a precise method to assess sensorimotor deficits up to 40 days after middle cerebral art...

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Detalles Bibliográficos
Autores principales: Ahmed, Jewel, Dwyer, Dominic M, Farr, Tracy D, Harrison, David J, Dunnett, Stephen B, Trueman, Rebecca C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305038/
https://www.ncbi.nlm.nih.gov/pubmed/28056584
http://dx.doi.org/10.1177/0271678X16684141
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author Ahmed, Jewel
Dwyer, Dominic M
Farr, Tracy D
Harrison, David J
Dunnett, Stephen B
Trueman, Rebecca C
author_facet Ahmed, Jewel
Dwyer, Dominic M
Farr, Tracy D
Harrison, David J
Dunnett, Stephen B
Trueman, Rebecca C
author_sort Ahmed, Jewel
collection PubMed
description The need for sensitive, easy to administer assessments of long-term functional deficits is crucial in pre-clinical stroke research. In the present study, we introduce lickometry (lick microstructure analysis) as a precise method to assess sensorimotor deficits up to 40 days after middle cerebral artery occlusion in rats. Impairments in drinking efficiency compared to controls, and a compensatory increase in the number of drinking clusters were observed. This highlights the utility of this easy to administer task in assessing subtle, long-term deficits, which could be likened to oral deficits in patients.
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spelling pubmed-53050382017-02-21 Lickometry: A novel and sensitive method for assessing functional deficits in rats after stroke Ahmed, Jewel Dwyer, Dominic M Farr, Tracy D Harrison, David J Dunnett, Stephen B Trueman, Rebecca C J Cereb Blood Flow Metab Brief Communication The need for sensitive, easy to administer assessments of long-term functional deficits is crucial in pre-clinical stroke research. In the present study, we introduce lickometry (lick microstructure analysis) as a precise method to assess sensorimotor deficits up to 40 days after middle cerebral artery occlusion in rats. Impairments in drinking efficiency compared to controls, and a compensatory increase in the number of drinking clusters were observed. This highlights the utility of this easy to administer task in assessing subtle, long-term deficits, which could be likened to oral deficits in patients. SAGE Publications 2017-01-06 2017-03 /pmc/articles/PMC5305038/ /pubmed/28056584 http://dx.doi.org/10.1177/0271678X16684141 Text en © The Author(s) 2016 http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Brief Communication
Ahmed, Jewel
Dwyer, Dominic M
Farr, Tracy D
Harrison, David J
Dunnett, Stephen B
Trueman, Rebecca C
Lickometry: A novel and sensitive method for assessing functional deficits in rats after stroke
title Lickometry: A novel and sensitive method for assessing functional deficits in rats after stroke
title_full Lickometry: A novel and sensitive method for assessing functional deficits in rats after stroke
title_fullStr Lickometry: A novel and sensitive method for assessing functional deficits in rats after stroke
title_full_unstemmed Lickometry: A novel and sensitive method for assessing functional deficits in rats after stroke
title_short Lickometry: A novel and sensitive method for assessing functional deficits in rats after stroke
title_sort lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305038/
https://www.ncbi.nlm.nih.gov/pubmed/28056584
http://dx.doi.org/10.1177/0271678X16684141
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