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Potential effect of spliceosome inhibition in small cell lung cancer irrespective of the MYC status

Small cell lung cancer (SCLC) is a highly aggressive malignancy with few therapeutic advances in the treatment in recent decades. Based on a recent study that identified the spliceosome as a therapeutic vulnerability in MYC-driven breast cancers, we evaluated the efficacy of a spliceosome inhibitor...

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Detalles Bibliográficos
Autores principales:	Suda, Kenichi, Rozeboom, Leslie, Yu, Hui, Ellison, Kim, Rivard, Christopher J., Mitsudomi, Tetsuya, Hirsch, Fred R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305228/ https://www.ncbi.nlm.nih.gov/pubmed/28192473 http://dx.doi.org/10.1371/journal.pone.0172209

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