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Optical coherence tomography segmentation analysis in relapsing remitting versus progressive multiple sclerosis

INTRODUCTION: Optical coherence tomography (OCT) with retinal segmentation analysis is a valuable tool in assessing axonal loss and neuro-degeneration in multiple sclerosis (MS) by in-vivo imaging, delineation and quantification of retinal layers. There is evidence of deep retinal involvement in MS...

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Autores principales: Behbehani, Raed, Abu Al-Hassan, Abdullah, Al-Salahat, Ali, Sriraman, Devarajan, Oakley, J. D., Alroughani, Raed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305239/
https://www.ncbi.nlm.nih.gov/pubmed/28192539
http://dx.doi.org/10.1371/journal.pone.0172120
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author Behbehani, Raed
Abu Al-Hassan, Abdullah
Al-Salahat, Ali
Sriraman, Devarajan
Oakley, J. D.
Alroughani, Raed
author_facet Behbehani, Raed
Abu Al-Hassan, Abdullah
Al-Salahat, Ali
Sriraman, Devarajan
Oakley, J. D.
Alroughani, Raed
author_sort Behbehani, Raed
collection PubMed
description INTRODUCTION: Optical coherence tomography (OCT) with retinal segmentation analysis is a valuable tool in assessing axonal loss and neuro-degeneration in multiple sclerosis (MS) by in-vivo imaging, delineation and quantification of retinal layers. There is evidence of deep retinal involvement in MS beyond the inner retinal layers. The ultra-structural retinal changes in MS in different MS phenotypes can reflect differences in the pathophysiologic mechanisms. There is limited data on the pattern of deeper retinal layer involvement in progressive MS (PMS) versus relapsing remitting MS (RRMS). We have compared the OCT segmentation analysis in patients with relapsing-remitting MS and progressive MS. METHODS: Cross-sectional study of 113 MS patients (226 eyes) (29 PMS, 84 RRMS) and 38 healthy controls (72 eyes). Spectral domain OCT (SDOCT) using the macular cube acquisition protocol (Cirrus HDOCT 5000; Carl Zeiss Meditec) and segmentation of the retinal layers for quantifying the thicknesses of the retinal layers. Segmentation of the retinal layers was carried out utilizing Orion software (Voxeleron, USA) for quantifying the thicknesses of individual retinal layers. RESULTS: The retinal nerve finer layer (RNFL) (p = 0.023), the ganglion-cell/inner plexiform layer (GCIPL) (p = 0.006) and the outer plexiform layer (OPL) (p = 0.033) were significantly thinner in PMS compared to RRMS. There was significant negative correlation between the outer nuclear layer (ONL) and EDSS (r = -0.554, p = 0.02) in PMS patients. In RRMS patients with prior optic neuritis, the GCIPL correlated negatively (r = -0.317; p = 0.046), while the photoreceptor layer (PR) correlated positively with EDSS (r = 0.478; p = 0.003). CONCLUSIONS: Patients with PMS exhibit more atrophy of both the inner and outer retinal layers than RRMS. The ONL in PMS and the GCIPL and PR in RRMS can serve as potential surrogate of disease burden and progression (EDSS). The specific retinal layer predilection and its correlation with disability may reflect different pathophysiologic mechanisms and various stages of progression in MS.
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spelling pubmed-53052392017-02-28 Optical coherence tomography segmentation analysis in relapsing remitting versus progressive multiple sclerosis Behbehani, Raed Abu Al-Hassan, Abdullah Al-Salahat, Ali Sriraman, Devarajan Oakley, J. D. Alroughani, Raed PLoS One Research Article INTRODUCTION: Optical coherence tomography (OCT) with retinal segmentation analysis is a valuable tool in assessing axonal loss and neuro-degeneration in multiple sclerosis (MS) by in-vivo imaging, delineation and quantification of retinal layers. There is evidence of deep retinal involvement in MS beyond the inner retinal layers. The ultra-structural retinal changes in MS in different MS phenotypes can reflect differences in the pathophysiologic mechanisms. There is limited data on the pattern of deeper retinal layer involvement in progressive MS (PMS) versus relapsing remitting MS (RRMS). We have compared the OCT segmentation analysis in patients with relapsing-remitting MS and progressive MS. METHODS: Cross-sectional study of 113 MS patients (226 eyes) (29 PMS, 84 RRMS) and 38 healthy controls (72 eyes). Spectral domain OCT (SDOCT) using the macular cube acquisition protocol (Cirrus HDOCT 5000; Carl Zeiss Meditec) and segmentation of the retinal layers for quantifying the thicknesses of the retinal layers. Segmentation of the retinal layers was carried out utilizing Orion software (Voxeleron, USA) for quantifying the thicknesses of individual retinal layers. RESULTS: The retinal nerve finer layer (RNFL) (p = 0.023), the ganglion-cell/inner plexiform layer (GCIPL) (p = 0.006) and the outer plexiform layer (OPL) (p = 0.033) were significantly thinner in PMS compared to RRMS. There was significant negative correlation between the outer nuclear layer (ONL) and EDSS (r = -0.554, p = 0.02) in PMS patients. In RRMS patients with prior optic neuritis, the GCIPL correlated negatively (r = -0.317; p = 0.046), while the photoreceptor layer (PR) correlated positively with EDSS (r = 0.478; p = 0.003). CONCLUSIONS: Patients with PMS exhibit more atrophy of both the inner and outer retinal layers than RRMS. The ONL in PMS and the GCIPL and PR in RRMS can serve as potential surrogate of disease burden and progression (EDSS). The specific retinal layer predilection and its correlation with disability may reflect different pathophysiologic mechanisms and various stages of progression in MS. Public Library of Science 2017-02-13 /pmc/articles/PMC5305239/ /pubmed/28192539 http://dx.doi.org/10.1371/journal.pone.0172120 Text en © 2017 Behbehani et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Behbehani, Raed
Abu Al-Hassan, Abdullah
Al-Salahat, Ali
Sriraman, Devarajan
Oakley, J. D.
Alroughani, Raed
Optical coherence tomography segmentation analysis in relapsing remitting versus progressive multiple sclerosis
title Optical coherence tomography segmentation analysis in relapsing remitting versus progressive multiple sclerosis
title_full Optical coherence tomography segmentation analysis in relapsing remitting versus progressive multiple sclerosis
title_fullStr Optical coherence tomography segmentation analysis in relapsing remitting versus progressive multiple sclerosis
title_full_unstemmed Optical coherence tomography segmentation analysis in relapsing remitting versus progressive multiple sclerosis
title_short Optical coherence tomography segmentation analysis in relapsing remitting versus progressive multiple sclerosis
title_sort optical coherence tomography segmentation analysis in relapsing remitting versus progressive multiple sclerosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305239/
https://www.ncbi.nlm.nih.gov/pubmed/28192539
http://dx.doi.org/10.1371/journal.pone.0172120
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