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Influence of False Lumen Status on the Prognosis of Acute Type A Aortic Dissection without Urgent Surgical Treatment

Aim: Recently, much attention has been focused on partial thrombosis of the false lumen in patients with acute aortic dissection. However, its effect on clinical outcomes in these patients, especially in case of acute type A aortic dissection, has not been clearly elucidated. This study evaluated th...

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Autores principales: Tanaka, Akihito, Ishii, Hideki, Suzuki, Susumu, Ota, Tomoyuki, Oshima, Hideki, Usui, Akihiko, Komori, Kimihiro, Murohara, Toyoaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Atherosclerosis Society 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305677/
https://www.ncbi.nlm.nih.gov/pubmed/27466158
http://dx.doi.org/10.5551/jat.35675
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author Tanaka, Akihito
Ishii, Hideki
Suzuki, Susumu
Ota, Tomoyuki
Oshima, Hideki
Usui, Akihiko
Komori, Kimihiro
Murohara, Toyoaki
author_facet Tanaka, Akihito
Ishii, Hideki
Suzuki, Susumu
Ota, Tomoyuki
Oshima, Hideki
Usui, Akihiko
Komori, Kimihiro
Murohara, Toyoaki
author_sort Tanaka, Akihito
collection PubMed
description Aim: Recently, much attention has been focused on partial thrombosis of the false lumen in patients with acute aortic dissection. However, its effect on clinical outcomes in these patients, especially in case of acute type A aortic dissection, has not been clearly elucidated. This study evaluated the influence of the false lumen status, including partial thrombosis, on short-term clinical outcomes in acute type A aortic dissection patients without urgent surgical treatment. Methods: Sixty-two patients (29 males, mean age 73 ± 13 years) with acute type A aortic dissection who did not receive urgent surgical treatment at four hospitals were enrolled. Patients were divided into three groups based on the false lumen status on enhanced computed tomography image (complete thrombosis, n = 28; partial thrombosis, n = 27; patent, n = 7). Patients with partial thrombosis were further divided into two groups (thrombus-dominant, n = 15; flow-dominant, n = 12). Results: The short-term mortality rate (in-hospital and 30-day) was significantly higher in patients with a patent false lumen, while no significant difference was seen between the other two groups. Patients with flow-dominant partial thrombosis had significantly higher short-term mortality rate than those with thrombus-dominant partial thrombosis (in-hospital, p = 0.001 and 30-day, p < 0.001). Conclusions: The short-term mortality rate in acute type A aortic dissection patients without urgent surgical treatment was lower in patients with partial thrombosis of the false lumen than in those with a patent false lumen. Furthermore, patients with flow-dominant partial thrombosis had higher mortality rate than those with thrombus-dominant partial thrombosis.
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spelling pubmed-53056772017-03-03 Influence of False Lumen Status on the Prognosis of Acute Type A Aortic Dissection without Urgent Surgical Treatment Tanaka, Akihito Ishii, Hideki Suzuki, Susumu Ota, Tomoyuki Oshima, Hideki Usui, Akihiko Komori, Kimihiro Murohara, Toyoaki J Atheroscler Thromb Original Article Aim: Recently, much attention has been focused on partial thrombosis of the false lumen in patients with acute aortic dissection. However, its effect on clinical outcomes in these patients, especially in case of acute type A aortic dissection, has not been clearly elucidated. This study evaluated the influence of the false lumen status, including partial thrombosis, on short-term clinical outcomes in acute type A aortic dissection patients without urgent surgical treatment. Methods: Sixty-two patients (29 males, mean age 73 ± 13 years) with acute type A aortic dissection who did not receive urgent surgical treatment at four hospitals were enrolled. Patients were divided into three groups based on the false lumen status on enhanced computed tomography image (complete thrombosis, n = 28; partial thrombosis, n = 27; patent, n = 7). Patients with partial thrombosis were further divided into two groups (thrombus-dominant, n = 15; flow-dominant, n = 12). Results: The short-term mortality rate (in-hospital and 30-day) was significantly higher in patients with a patent false lumen, while no significant difference was seen between the other two groups. Patients with flow-dominant partial thrombosis had significantly higher short-term mortality rate than those with thrombus-dominant partial thrombosis (in-hospital, p = 0.001 and 30-day, p < 0.001). Conclusions: The short-term mortality rate in acute type A aortic dissection patients without urgent surgical treatment was lower in patients with partial thrombosis of the false lumen than in those with a patent false lumen. Furthermore, patients with flow-dominant partial thrombosis had higher mortality rate than those with thrombus-dominant partial thrombosis. Japan Atherosclerosis Society 2017-02-01 /pmc/articles/PMC5305677/ /pubmed/27466158 http://dx.doi.org/10.5551/jat.35675 Text en 2017 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License. http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Original Article
Tanaka, Akihito
Ishii, Hideki
Suzuki, Susumu
Ota, Tomoyuki
Oshima, Hideki
Usui, Akihiko
Komori, Kimihiro
Murohara, Toyoaki
Influence of False Lumen Status on the Prognosis of Acute Type A Aortic Dissection without Urgent Surgical Treatment
title Influence of False Lumen Status on the Prognosis of Acute Type A Aortic Dissection without Urgent Surgical Treatment
title_full Influence of False Lumen Status on the Prognosis of Acute Type A Aortic Dissection without Urgent Surgical Treatment
title_fullStr Influence of False Lumen Status on the Prognosis of Acute Type A Aortic Dissection without Urgent Surgical Treatment
title_full_unstemmed Influence of False Lumen Status on the Prognosis of Acute Type A Aortic Dissection without Urgent Surgical Treatment
title_short Influence of False Lumen Status on the Prognosis of Acute Type A Aortic Dissection without Urgent Surgical Treatment
title_sort influence of false lumen status on the prognosis of acute type a aortic dissection without urgent surgical treatment
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305677/
https://www.ncbi.nlm.nih.gov/pubmed/27466158
http://dx.doi.org/10.5551/jat.35675
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