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The Evolutionary Relationship between Alternative Splicing and Gene Duplication

The protein diversity that exists today has resulted from various evolutionary processes. It is well known that gene duplication (GD) along with the accumulation of mutations are responsible, among other factors, for an increase in the number of different proteins. The gene structure in eukaryotes r...

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Autores principales: Iñiguez, Luis P., Hernández, Georgina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306129/
https://www.ncbi.nlm.nih.gov/pubmed/28261262
http://dx.doi.org/10.3389/fgene.2017.00014
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author Iñiguez, Luis P.
Hernández, Georgina
author_facet Iñiguez, Luis P.
Hernández, Georgina
author_sort Iñiguez, Luis P.
collection PubMed
description The protein diversity that exists today has resulted from various evolutionary processes. It is well known that gene duplication (GD) along with the accumulation of mutations are responsible, among other factors, for an increase in the number of different proteins. The gene structure in eukaryotes requires the removal of non-coding sequences, introns, to produce mature mRNAs. This process, known as cis-splicing, referred to here as splicing, is regulated by several factors which can lead to numerous splicing arrangements, commonly designated as alternative splicing (AS). AS, producing several transcripts isoforms form a single gene, also increases the protein diversity. However, the evolution and manner for increasing protein variation differs between AS and GD. An important question is how are patterns of AS affected after a GD event. Here, we review the current knowledge of AS and GD, focusing on their evolutionary relationship. These two processes are now considered the main contributors to the increasing protein diversity and therefore their relationship is a relevant, yet understudied, area of evolutionary study.
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spelling pubmed-53061292017-03-03 The Evolutionary Relationship between Alternative Splicing and Gene Duplication Iñiguez, Luis P. Hernández, Georgina Front Genet Genetics The protein diversity that exists today has resulted from various evolutionary processes. It is well known that gene duplication (GD) along with the accumulation of mutations are responsible, among other factors, for an increase in the number of different proteins. The gene structure in eukaryotes requires the removal of non-coding sequences, introns, to produce mature mRNAs. This process, known as cis-splicing, referred to here as splicing, is regulated by several factors which can lead to numerous splicing arrangements, commonly designated as alternative splicing (AS). AS, producing several transcripts isoforms form a single gene, also increases the protein diversity. However, the evolution and manner for increasing protein variation differs between AS and GD. An important question is how are patterns of AS affected after a GD event. Here, we review the current knowledge of AS and GD, focusing on their evolutionary relationship. These two processes are now considered the main contributors to the increasing protein diversity and therefore their relationship is a relevant, yet understudied, area of evolutionary study. Frontiers Media S.A. 2017-02-14 /pmc/articles/PMC5306129/ /pubmed/28261262 http://dx.doi.org/10.3389/fgene.2017.00014 Text en Copyright © 2017 Iñiguez and Hernández. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Iñiguez, Luis P.
Hernández, Georgina
The Evolutionary Relationship between Alternative Splicing and Gene Duplication
title The Evolutionary Relationship between Alternative Splicing and Gene Duplication
title_full The Evolutionary Relationship between Alternative Splicing and Gene Duplication
title_fullStr The Evolutionary Relationship between Alternative Splicing and Gene Duplication
title_full_unstemmed The Evolutionary Relationship between Alternative Splicing and Gene Duplication
title_short The Evolutionary Relationship between Alternative Splicing and Gene Duplication
title_sort evolutionary relationship between alternative splicing and gene duplication
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306129/
https://www.ncbi.nlm.nih.gov/pubmed/28261262
http://dx.doi.org/10.3389/fgene.2017.00014
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