Cargando…

Ocular Drug Distribution After Topical Administration: Population Pharmacokinetic Model in Rabbits

BACKGROUND AND OBJECTIVE: When eye diseases are treated by topical administration, the success of treatment lies in the effective drug concentration in the target tissue. This is why the drug’s pharmacokinetic, in the different substructures of the eye, needs to be explored more accurately during dr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Djebli, Nassim, Khier, Sonia, Griguer, Florence, Coutant, Anne-Laure, Tavernier, Alexandra, Fabre, Gerard, Leriche, Caroline, Fabre, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2016
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306244/ https://www.ncbi.nlm.nih.gov/pubmed/26820265 http://dx.doi.org/10.1007/s13318-016-0319-4

Ejemplares similares

Combined Semi-mechanistic Target-Mediated Drug Disposition and Pharmacokinetic–Pharmacodynamic Models of Alirocumab, PCSK9, and Low-Density Lipoprotein Cholesterol in a Pooled Analysis of Randomized Phase I/II/III Studies
por: Nolain, Patrick, et al.
Publicado: (2022)

Target-Mediated Drug Disposition Population Pharmacokinetics Model of Alirocumab in Healthy Volunteers and Patients: Pooled Analysis of Randomized Phase I/II/III Studies
por: Djebli, Nassim, et al.
Publicado: (2017)

Prior information for population pharmacokinetic and pharmacokinetic/pharmacodynamic analysis: overview and guidance with a focus on the NONMEM PRIOR subroutine
por: Chan Kwong, Anna H.-X. P., et al.
Publicado: (2020)

Pharmacokinetics of pirfenidone after topical administration in rabbit eye
por: Sun, Guoying, et al.
Publicado: (2011)

Population Pharmacokinetic/Pharmacodynamic Analysis of Alirocumab in Healthy Volunteers or Hypercholesterolemic Subjects Using an Indirect Response Model to Predict Low-Density Lipoprotein Cholesterol Lowering: Support for a Biologics License Application Submission: Part II
por: Nicolas, Xavier, et al.
Publicado: (2018)

Pharmacokinetics of Uridine Following Ocular, Oral and Intravenous Administration in Rabbits
por: Kim, Eunyoung, et al.
Publicado: (2013)

Ocular and Systemic Pharmacokinetics of Brimonidine and Timolol After Topical Administration in Rabbits: Comparison Between Fixed-Combination and Single Drugs
por: Suzuki, Gen, et al.
Publicado: (2020)

Ocular Distribution of Cyclosporine Following Topical Administration of OTX-101 in New Zealand White Rabbits
por: Weiss, Sidney L., et al.
Publicado: (2019)

Comparative Assessment of Distribution Characteristics and Ocular Pharmacokinetics of Norvancomycin Between Continuous Topical Ocular Instillation and Hourly Administration of Eye Drop
por: Lin, Wenxiang, et al.
Publicado: (2020)

Comparative Study of Ocular Pharmacokinetics of Topical 0.3% Gatifloxacin Eye Gel and Solution in Rabbits
por: Liu, Manli, et al.
Publicado: (2022)

Pharmacokinetics and Tissue Distribution of Minocycline following Intravenous Administration in Rabbits
por: Petraitis, Vidmantas, et al.
Publicado: (2017)

Ocular Distribution and Pharmacokinetics of Lifitegrast in Pigmented Rabbits and Mass Balance in Beagle Dogs
por: Chung, Jou-Ku, et al.
Publicado: (2018)

Bio-Distribution and Pharmacokinetics of Topically Administered γ-Cyclodextrin Based Eye Drops in Rabbits
por: Kallab, Martin, et al.
Publicado: (2021)

Characteristics of corneal phospholipidosis induced by topical ocular application of chloroquine and amiodarone in rabbits
por: Yamagiwa, Yoshinori, et al.
Publicado: (2016)

Assessment to the Antifungal Effects in vitro and the Ocular Pharmacokinetics of Solid-Lipid Nanoparticle in Rabbits
por: Liang, Zhen, et al.
Publicado: (2021)

Modification of pharmacokinetics of norfloxacin following oral administration of curcumin in rabbits
por: Pavithra, B. H., et al.
Publicado: (2009)

Pharmacokinetics of cytisine after single intravenous and oral administration in rabbits
por: Astroug, Henri, et al.
Publicado: (2010)

MALDI imaging mass spectrometry revealed atropine distribution in the ocular tissues and its transit from anterior to posterior regions in the whole-eye of rabbit after topical administration
por: Mori, Naoto, et al.
Publicado: (2019)

Suprachoroidal Injection of Triamcinolone Acetonide Suspension: Ocular Pharmacokinetics and Distribution in Rabbits Demonstrates High and Durable Levels in the Chorioretina
por: Muya, Leroy, et al.
Publicado: (2022)

Pharmacokinetics of bevacizumab after topical and intravitreal administration in human eyes
por: Moisseiev, Elad, et al.
Publicado: (2013)

Perspectives of Positively Charged Nanocrystals of Tedizolid Phosphate as a Topical Ocular Application in Rabbits
por: Alshememry, Abdullah, et al.
Publicado: (2022)

Pharmacokinetics and efficacy of a ketorolac-loaded ocular coil in New Zealand white rabbits
por: Bertens, Christian J. F., et al.
Publicado: (2021)

Pharmacokinetics of placental protein 13 after intravenous and subcutaneous administration in rabbits
por: Drobnjak, Tijana, et al.
Publicado: (2018)

The effects of oral administration of Cola nitida on the pharmacokinetic profile of metoclopramide in rabbits
por: Amadi, Cecilia Nwadiuto, et al.
Publicado: (2020)

Entrectinib dose confirmation in pediatric oncology patients: pharmacokinetic considerations
por: Meneses-Lorente, Georgina, et al.
Publicado: (2023)

An Evaluation of the in vivo Safety of Nonporous Silica Nanoparticles: Ocular Topical Administration versus Oral Administration
por: Kim, Martha, et al.
Publicado: (2017)

Pharmacokinetics and Efficacy of Topically Applied Nonsteroidal Anti-Inflammatory Drugs in Retinochoroidal Tissues in Rabbits
por: Kida, Tetsuo, et al.
Publicado: (2014)

Treatment of Severe Acute Bacterial Keratitis in Rabbits Using Continuous Topical Ocular Instillation with Norvancomycin
por: Lin, Wenxiang, et al.
Publicado: (2021)

Pharmacokinetic evaluation of D-ribose after oral and intravenous administration to healthy rabbits
por: Alzoubi, Karem H, et al.
Publicado: (2018)

Pharmacokinetics of Azithromycin, Levofloxacin, and Ofloxacin in Rabbit Extraocular Tissues After Ophthalmic Administration
por: Sakai, Tatsuya, et al.
Publicado: (2019)

Concentrations of besifloxacin, gatifloxacin, and moxifloxacin in human conjunctiva after topical ocular administration
por: Torkildsen, Gail, et al.
Publicado: (2010)

The effect of topical administration of cyclopentolate on ocular biometry: An analysis for mouse and human models
por: Huang, Furong, et al.
Publicado: (2017)

Nanoemulsion Based Vehicle for Effective Ocular Delivery of Moxifloxacin Using Experimental Design and Pharmacokinetic Study in Rabbits
por: Shah, Jigar, et al.
Publicado: (2019)

Pharmacological and pharmacokinetic profile of the novel ocular hypotensive prodrug CKLP1 in Dutch-belted pigmented rabbits
por: Roy Chowdhury, Uttio, et al.
Publicado: (2020)

Comparative pharmacokinetics of fluralaner in dogs and cats following single topical or intravenous administration
por: Kilp, Susanne, et al.
Publicado: (2016)

Characterization of the pharmacokinetics of entrectinib and its active M5 metabolite in healthy volunteers and patients with solid tumors
por: Meneses-Lorente, Georgina, et al.
Publicado: (2021)

Pharmacokinetic profiles of levofloxacin after intravenous, intramuscular and subcutaneous administration to rabbits (Oryctolagus cuniculus)
por: Sitovs, Andrejs, et al.
Publicado: (2020)

Pharmacokinetic Assessment of Staphylococcal Phage K Following Parenteral and Intra-articular Administration in Rabbits
por: Totten, Katherine M.C., et al.
Publicado: (2022)

Gelatin Nanoparticles-HPMC Hybrid System for Effective Ocular Topical Administration of Antihypertensive Agents
por: Esteban-Pérez, Sergio, et al.
Publicado: (2020)

Improving the topical ocular pharmacokinetics of lyophilized cyclosporine A-loaded micelles: formulation, in vitro and in vivo studies
por: Yu, Yinglan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_nd75l92bfsst9lgr2iio3ahme4