The Coordination Abilities of New Cyclic Analogs of Somatostatin

Two new somatostatin analogs with a characteristic part of the sequence -c(Cys-Phe-Trp-Lys-Thr-Cys)- and with two histidine and two aspartic acid moieties in their structures were synthesized and analyzed in terms of their coordination abilities with copper (II) ions. Both peptides bind Cu(II) effec...

Descripción completa

Detalles Bibliográficos
Autores principales: Marciniak, Aleksandra, Cebrat, Marek, Brasuń, Justyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306305/
https://www.ncbi.nlm.nih.gov/pubmed/28250719
http://dx.doi.org/10.1007/s10989-016-9546-4
Descripción
Sumario:Two new somatostatin analogs with a characteristic part of the sequence -c(Cys-Phe-Trp-Lys-Thr-Cys)- and with two histidine and two aspartic acid moieties in their structures were synthesized and analyzed in terms of their coordination abilities with copper (II) ions. Both peptides bind Cu(II) effectively. Ligands form 4N complexes with [Formula: see text] binding mode in a basic range of pH. But in spite of very similar sequences of the two peptides a significant difference in the effectiveness of the binding of copper (II) ions was observed.

Ejemplares similares