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Vaccination with Altered Peptide Ligands of a Plasmodium berghei Circumsporozoite Protein CD8 T-Cell Epitope: A Model to Generate T Cells Resistant to Immune Interference by Polymorphic Epitopes

Many pathogens, including the malaria parasite Plasmodium falciparum, display high levels of polymorphism within T-cell epitope regions of proteins associated with protective immunity. The T-cell epitope variants are often non-cross-reactive. Herein, we show in a murine model, which modifies a prote...

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Detalles Bibliográficos
Autores principales:	Minigo, Gabriela, Flanagan, Katie L., Slattery, Robyn M., Plebanski, Magdalena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306364/ https://www.ncbi.nlm.nih.gov/pubmed/28261200 http://dx.doi.org/10.3389/fimmu.2017.00115

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