In patients with chronic aplastic anemia, bone marrow–derived MSCs regulate the Treg/Th17 balance by influencing the Notch/RBP-J/FOXP3/RORγt pathway

The standard treatment for aplastic anemia (AA) in young patients is a matched sibling hematopoietic stem cell transplant. Transfusion of a chronic AA patient with allogeneic bone marrow–derived mesenchymal stromal cells (BMMSCs) is currently being developed as a cell-based therapy, and the safety a...

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Detalles Bibliográficos
Autores principales: Li, Hongbo, Wang, Lin, Pang, Yan, Jiang, Zujun, Liu, Zenghui, Xiao, Haowen, Chen, Haijia, Ge, Xiaohu, Lan, Hai, Xiao, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307358/
https://www.ncbi.nlm.nih.gov/pubmed/28195151
http://dx.doi.org/10.1038/srep42488

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