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Resistance of Shigella strains to extended-spectrum cephalosporins in Isfahan province
Background: The aim of this study was to determine the serotypes and antimicrobial susceptibility of Shigella spp. in Isfahan, (Iran) from 2010 to 2015. Methods: This retrospective study was conducted on Shigella isolates in four tertiary care hospitals. The process of bacterial isolation and determ...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iran University of Medical Sciences
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307619/ https://www.ncbi.nlm.nih.gov/pubmed/28210593 |
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author | Mostafavi, Nasser Bighamian, Moein Mobasherizade, Sina Kelishadi, Roya |
author_facet | Mostafavi, Nasser Bighamian, Moein Mobasherizade, Sina Kelishadi, Roya |
author_sort | Mostafavi, Nasser |
collection | PubMed |
description | Background: The aim of this study was to determine the serotypes and antimicrobial susceptibility of Shigella spp. in Isfahan, (Iran) from 2010 to 2015. Methods: This retrospective study was conducted on Shigella isolates in four tertiary care hospitals. The process of bacterial isolation and determination of susceptibility was performed by standard microbiological guidelines. The patients were categorized into three age groups of under 5, 5-15 and over 15 years. Results: Among 45 isolates, S. sonnei (63.6%) was the predominant species, followed by S. flexneri (34.1%), and S. dysenteriae (2.3%). Substantial resistance to ampicillin, trimethoprim- sulfamethoxazole, ceftriaxone, cefotaxime, and cefixime was observed. Over 94% of the isolates were sensitive to ciprofloxacin. Susceptibility of isolates was similar between all age groups. Conclusion: Significant resistance to third generation cephalosporins precludes the use of these agents for empirical treatment of shigellosis in our population. Ciprofloxacin is an appropriate option; however, susceptibility tests should be performed before prescription. |
format | Online Article Text |
id | pubmed-5307619 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Iran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-53076192017-02-16 Resistance of Shigella strains to extended-spectrum cephalosporins in Isfahan province Mostafavi, Nasser Bighamian, Moein Mobasherizade, Sina Kelishadi, Roya Med J Islam Repub Iran Original Article Background: The aim of this study was to determine the serotypes and antimicrobial susceptibility of Shigella spp. in Isfahan, (Iran) from 2010 to 2015. Methods: This retrospective study was conducted on Shigella isolates in four tertiary care hospitals. The process of bacterial isolation and determination of susceptibility was performed by standard microbiological guidelines. The patients were categorized into three age groups of under 5, 5-15 and over 15 years. Results: Among 45 isolates, S. sonnei (63.6%) was the predominant species, followed by S. flexneri (34.1%), and S. dysenteriae (2.3%). Substantial resistance to ampicillin, trimethoprim- sulfamethoxazole, ceftriaxone, cefotaxime, and cefixime was observed. Over 94% of the isolates were sensitive to ciprofloxacin. Susceptibility of isolates was similar between all age groups. Conclusion: Significant resistance to third generation cephalosporins precludes the use of these agents for empirical treatment of shigellosis in our population. Ciprofloxacin is an appropriate option; however, susceptibility tests should be performed before prescription. Iran University of Medical Sciences 2016-10-17 /pmc/articles/PMC5307619/ /pubmed/28210593 Text en © 2016 Iran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Original Article Mostafavi, Nasser Bighamian, Moein Mobasherizade, Sina Kelishadi, Roya Resistance of Shigella strains to extended-spectrum cephalosporins in Isfahan province |
title |
Resistance of Shigella strains to extended-spectrum cephalosporins in Isfahan province
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title_full |
Resistance of Shigella strains to extended-spectrum cephalosporins in Isfahan province
|
title_fullStr |
Resistance of Shigella strains to extended-spectrum cephalosporins in Isfahan province
|
title_full_unstemmed |
Resistance of Shigella strains to extended-spectrum cephalosporins in Isfahan province
|
title_short |
Resistance of Shigella strains to extended-spectrum cephalosporins in Isfahan province
|
title_sort | resistance of shigella strains to extended-spectrum cephalosporins in isfahan province |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307619/ https://www.ncbi.nlm.nih.gov/pubmed/28210593 |
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