First insight into the somatic mutation burden of neurofibromatosis type 2-associated grade I and grade II meningiomas: a case report comprehensive genomic study of two cranial meningiomas with vastly different clinical presentation

BACKGROUND: Neurofibromatosis type 2 (NF2) is a rare autosomal dominant nervous system tumor predisposition disorder caused by constitutive inactivation of one of the two copies of NF2. Meningiomas affect about one half of NF2 patients, and are associated with a higher disease burden. Currently, the...

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Detalles Bibliográficos
Autores principales: Dewan, Ramita, Pemov, Alexander, Dutra, Amalia S., Pak, Evgenia D., Edwards, Nancy A., Ray-Chaudhury, Abhik, Hansen, Nancy F., Chandrasekharappa, Settara C., Mullikin, James C., Asthagiri, Ashok R., Heiss, John D., Stewart, Douglas R., Germanwala, Anand V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307647/
https://www.ncbi.nlm.nih.gov/pubmed/28193203
http://dx.doi.org/10.1186/s12885-017-3127-6

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