Opportunities and challenges of whole-genome and -exome sequencing

Recent advances in the development of sequencing technologies provide researchers with unprecedented possibilities for genetic analyses. In this review, we will discuss the history of genetic studies and the progress driven by next-generation sequencing (NGS), using complex inflammatory bowel diseas...

Descripción completa

Detalles Bibliográficos
Autores principales: Petersen, Britt-Sabina, Fredrich, Broder, Hoeppner, Marc P., Ellinghaus, David, Franke, Andre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307692/
https://www.ncbi.nlm.nih.gov/pubmed/28193154
http://dx.doi.org/10.1186/s12863-017-0479-5
Descripción
Sumario:Recent advances in the development of sequencing technologies provide researchers with unprecedented possibilities for genetic analyses. In this review, we will discuss the history of genetic studies and the progress driven by next-generation sequencing (NGS), using complex inflammatory bowel diseases as an example. We focus on the opportunities, but also challenges that researchers are facing when working with NGS data to unravel the genetic causes underlying diseases.

Ejemplares similares