Opportunities and challenges of whole-genome and -exome sequencing

Recent advances in the development of sequencing technologies provide researchers with unprecedented possibilities for genetic analyses. In this review, we will discuss the history of genetic studies and the progress driven by next-generation sequencing (NGS), using complex inflammatory bowel diseas...

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Autores principales: Petersen, Britt-Sabina, Fredrich, Broder, Hoeppner, Marc P., Ellinghaus, David, Franke, Andre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307692/
https://www.ncbi.nlm.nih.gov/pubmed/28193154
http://dx.doi.org/10.1186/s12863-017-0479-5
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author Petersen, Britt-Sabina
Fredrich, Broder
Hoeppner, Marc P.
Ellinghaus, David
Franke, Andre
author_facet Petersen, Britt-Sabina
Fredrich, Broder
Hoeppner, Marc P.
Ellinghaus, David
Franke, Andre
author_sort Petersen, Britt-Sabina
collection PubMed
description Recent advances in the development of sequencing technologies provide researchers with unprecedented possibilities for genetic analyses. In this review, we will discuss the history of genetic studies and the progress driven by next-generation sequencing (NGS), using complex inflammatory bowel diseases as an example. We focus on the opportunities, but also challenges that researchers are facing when working with NGS data to unravel the genetic causes underlying diseases.
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spelling pubmed-53076922017-02-22 Opportunities and challenges of whole-genome and -exome sequencing Petersen, Britt-Sabina Fredrich, Broder Hoeppner, Marc P. Ellinghaus, David Franke, Andre BMC Genet Review Recent advances in the development of sequencing technologies provide researchers with unprecedented possibilities for genetic analyses. In this review, we will discuss the history of genetic studies and the progress driven by next-generation sequencing (NGS), using complex inflammatory bowel diseases as an example. We focus on the opportunities, but also challenges that researchers are facing when working with NGS data to unravel the genetic causes underlying diseases. BioMed Central 2017-02-14 /pmc/articles/PMC5307692/ /pubmed/28193154 http://dx.doi.org/10.1186/s12863-017-0479-5 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Petersen, Britt-Sabina
Fredrich, Broder
Hoeppner, Marc P.
Ellinghaus, David
Franke, Andre
Opportunities and challenges of whole-genome and -exome sequencing
title Opportunities and challenges of whole-genome and -exome sequencing
title_full Opportunities and challenges of whole-genome and -exome sequencing
title_fullStr Opportunities and challenges of whole-genome and -exome sequencing
title_full_unstemmed Opportunities and challenges of whole-genome and -exome sequencing
title_short Opportunities and challenges of whole-genome and -exome sequencing
title_sort opportunities and challenges of whole-genome and -exome sequencing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307692/
https://www.ncbi.nlm.nih.gov/pubmed/28193154
http://dx.doi.org/10.1186/s12863-017-0479-5
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