A comparison of reference-based algorithms for correcting cell-type heterogeneity in Epigenome-Wide Association Studies

BACKGROUND: Intra-sample cellular heterogeneity presents numerous challenges to the identification of biomarkers in large Epigenome-Wide Association Studies (EWAS). While a number of reference-based deconvolution algorithms have emerged, their potential remains underexplored and a comparative evalua...

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Detalles Bibliográficos
Autores principales: Teschendorff, Andrew E., Breeze, Charles E., Zheng, Shijie C., Beck, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307731/
https://www.ncbi.nlm.nih.gov/pubmed/28193155
http://dx.doi.org/10.1186/s12859-017-1511-5

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