Cargando…
Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production
BACKGROUND: Alzheimer’s disease (AD)-linked protein, presenilin 1 (PS1), is present at the synapse, and the knock-out of presenilin in mice leads to synaptic dysfunction. On the other hand, synaptic activity was shown to influence PS1-dependent generation of distinct amyloid β (Aβ) species. However,...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307796/ https://www.ncbi.nlm.nih.gov/pubmed/28193235 http://dx.doi.org/10.1186/s13024-017-0159-y |