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Phosphorylation-dependent regulation of ALDH1A1 by Aurora kinase A: insights on their synergistic relationship in pancreatic cancer

BACKGROUND: Epithelial-to-mesenchymal transition (EMT) and cancer stem cell (CSC) formation are key underlying causes that promote extensive metastasis, drug resistance, and tumor recurrence in highly lethal pancreatic cancer. The mechanisms leading to EMT and CSC phenotypes are not fully understood...

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Detalles Bibliográficos
Autores principales:	Wang, Jing, Nikhil, Kumar, Viccaro, Keith, Chang, Lei, White, Jacoba, Shah, Kavita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307883/ https://www.ncbi.nlm.nih.gov/pubmed/28193222 http://dx.doi.org/10.1186/s12915-016-0335-5

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