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Selective detection of N6-methyladenine in DNA via metal ion-mediated replication and rolling circle amplification

N6-methyladenine (6mA) is reported as a potential epigenetic marker in eukaryotic genomes. However, accurate identification of the location of 6mA in DNA remains a challenging task. Here, we show that Ag(+) can selectively stabilize the A–C mismatch and efficiently promote primer extension. In contr...

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Detalles Bibliográficos
Autores principales:	Hong, Tingting, Yuan, Yushu, Wang, Tianlu, Ma, Jingwei, Yao, Qian, Hua, Xiaoluan, Xia, Yu, Zhou, Xiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2017
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308289/ https://www.ncbi.nlm.nih.gov/pubmed/28451166 http://dx.doi.org/10.1039/c6sc02271e

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