Cargando…

Phenotypic consequences of somatic mutations in the ataxia-telangiectasia mutated gene in non-small cell lung cancer

Mutations in the Ataxia-telangiectasia mutated (ATM) gene are frequently found in human cancers, including non-small cell lung cancer (NSCLC). Loss of ATM function confers sensitivity to ionising radiation (IR) and topoisomerase inhibitors and may thus define a subset of cancer patients that could g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Weber, Anika Maria, Drobnitzky, Neele, Devery, Aoife Maire, Bokobza, Sivan Mili, Adams, Richard A., Maughan, Timothy S., Ryan, Anderson Joseph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308618/ https://www.ncbi.nlm.nih.gov/pubmed/27602502 http://dx.doi.org/10.18632/oncotarget.11845

Ejemplares similares

Combining AKT inhibition with chloroquine and gefitinib prevents compensatory autophagy and induces cell death in EGFR mutated NSCLC cells
por: Bokobza, Sivan M., et al.
Publicado: (2014)

Vascular endothelial growth factor directly stimulates tumour cell proliferation in non-small cell lung cancer
por: DEVERY, AOIFE M., et al.
Publicado: (2015)

Age-related somatic mutations in the cancer genome
por: Milholland, Brandon, et al.
Publicado: (2015)

Ataxia-Telangiectasia Mutated Loss of Heterozygosity in Melanoma
por: Pastorino, Lorenza, et al.
Publicado: (2022)

Ataxia-Telangiectasia Mutated Is Involved in Autolysosome Formation
por: Hwang, Mihwa, et al.
Publicado: (2023)

Association of Ataxia Telangiectasia Mutated (ATM) gene mutation/deletion with Rhabdomyosarcoma
por: Zhang, Peilin, et al.
Publicado: (2003)

Identification of ATM Mutations in Korean Siblings with Ataxia-Telangiectasia
por: Huh, Hee Jae, et al.
Publicado: (2013)

Ataxia-Telangiectasia with Novel Splicing Mutations in the ATM Gene
por: Jeong, Heejeong, et al.
Publicado: (2014)

Ataxia-Telangiectasia Mutated Modulation of Carbon Metabolism in Cancer
por: Dahl, Erika S., et al.
Publicado: (2017)

Ataxia-Telangiectasia Mutated Kinase: Role in Myocardial Remodeling
por: Thrasher, Patsy, et al.
Publicado: (2016)

Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality
por: Jiang, Yanyan, et al.
Publicado: (2016)

Quantitative Phosphoproteomics of the Ataxia Telangiectasia-Mutated (ATM) and Ataxia Telangiectasia-Mutated and Rad3-related (ATR) Dependent DNA Damage Response in Arabidopsis thaliana
por: Roitinger, Elisabeth, et al.
Publicado: (2015)

Clinicopathological significance of ataxia telangiectasia-mutated (ATM) kinase and ataxia telangiectasia-mutated and Rad3-related (ATR) kinase in MYC overexpressed breast cancers
por: Savva, Constantinos, et al.
Publicado: (2019)

Association of Ataxia Telangiectasia Mutated (ATM) Gene Mutation/Deletion with Rhabdomyosarcoma – retraction
por: Zhang, Peilin, et al.
Publicado: (2003)

MEK inhibitors block growth of lung tumours with mutations in ataxia–telangiectasia mutated
por: Smida, Michal, et al.
Publicado: (2016)

Radiosensitive melanoma cell line with mutation of the gene for ataxia telangiectasia.
por: Ramsay, J., et al.
Publicado: (1998)

Dystonia in Ataxia Telangiectasia: A Case Report with Novel Mutations
por: Zaki-Dizaji, Majid, et al.
Publicado: (2020)

Mechanisms Underlying the Suppression of Chromosome Rearrangements by Ataxia-Telangiectasia Mutated
por: Yamauchi, Motohiro
Publicado: (2021)

Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress
por: Howes, Anna C., et al.
Publicado: (2023)

Combined poly-ADP ribose polymerase and ataxia-telangiectasia mutated/Rad3-related inhibition targets ataxia-telangiectasia mutated-deficient lung cancer cells
por: Jette, Nicholas R., et al.
Publicado: (2019)

BRCA somatic and germline mutation detection in paraffin embedded ovarian cancers by next-generation sequencing
por: Mafficini, Andrea, et al.
Publicado: (2016)

Correction: Combined poly-ADP ribose polymerase and ataxia-telangiectasia mutated/Rad3-related inhibition targets ataxia-telangiectasia mutated-deficient lung cancer cells
por: Jette, Nicholas R., et al.
Publicado: (2020)

Twelve Novel Atm Mutations Identified in Chinese Ataxia Telangiectasia Patients
por: Huang, Yu, et al.
Publicado: (2013)

The Role of the DNA Damage Response Kinase Ataxia Telangiectasia Mutated in Neuroprotection
por: Marinoglou, Konstantina
Publicado: (2012)

Ataxia-Telangiectasia Mutated is located in cardiac mitochondria and impacts oxidative phosphorylation
por: Blignaut, Marguerite, et al.
Publicado: (2019)

A new ataxia-telangiectasia mutation in an 11-year-old female
por: Mortaz, Esmaeil, et al.
Publicado: (2017)

Ataxia-telangiectasia mutated plays an important role in cerebellar integrity and functionality
por: Mitiagin, Yulia, et al.
Publicado: (2022)

Acute vascular response to cediranib treatment in human non-small-cell lung cancer xenografts with different tumour stromal architecture
por: Jiang, Yanyan, et al.
Publicado: (2015)

Severe reaction to radiotherapy provoked by hypomorphic germline mutations in ATM (ataxia–telangiectasia mutated gene)
por: Asadollahi, Reza, et al.
Publicado: (2020)

Thyroid and Breast Cancer in 2 Sisters With Monoallelic Mutations in the Ataxia Telangiectasia Mutated (ATM) Gene
por: Miasaki, Fabíola Y, et al.
Publicado: (2022)

Ataxia telangiectasia mutated (ATM) interacts with p400 ATPase for an efficient DNA damage response
por: Smith, Rebecca J., et al.
Publicado: (2016)

Erratum to: Twelve Novel Atm Mutations Identified in Chinese Ataxia Telangiectasia Patients
por: Huang, Yu, et al.
Publicado: (2013)

Telomere length, ATM mutation status and cancer risk in Ataxia-Telangiectasia families
por: Renault, Anne-Laure, et al.
Publicado: (2017)

The role of the ataxia telangiectasia mutated gene in lung cancer: recent advances in research
por: Xu, Yanling, et al.
Publicado: (2017)

A Novel Splice Site Mutation of the ATM Gene Associated with Ataxia Telangiectasia
por: SAEIDI, Kolsoum, et al.
Publicado: (2018)

Haplodeficiency of Ataxia Telangiectasia Mutated Accelerates Heart Failure After Myocardial Infarction
por: Jia, Lixin, et al.
Publicado: (2017)

A Rare Case of Ataxia-Telangiectasia-Like Disorder With MRE11 Mutation
por: Mahale, Rohan R, et al.
Publicado: (2020)

Myoclonus in Ataxia–Telangiectasia
por: Termsarasab, Pichet, et al.
Publicado: (2015)

Growth in ataxia telangiectasia
por: Natale, Valerie A. I., et al.
Publicado: (2021)

Novel homozygous ataxia-telangiectasia (A-T) mutated gene mutation identified in a Chinese pedigree with A-T
por: Chen, Weicheng, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_5utak3cglq998e26ue47i3av1m