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Repair of UVB-induced DNA damage is reduced in melanoma due to low XPC and global genome repair
UVB exposure leads to DNA damage, which when unrepaired induces C>T transitions. These mutations are found throughout the melanoma genome, particularly in non-transcribed regions. The global genome repair (GGR) branch of nucleotide excision repair (NER) is responsible for repairing UV-induced DNA...
Autores principales: | Budden, Timothy, Davey, Ryan J., Vilain, Ricardo E., Ashton, Katie A., Braye, Stephen G., Beveridge, Natalie J., Bowden, Nikola A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308628/ https://www.ncbi.nlm.nih.gov/pubmed/27487145 http://dx.doi.org/10.18632/oncotarget.10902 |
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