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Novel B55α-PP2A mutations in AML promote AKT T308 phosphorylation and sensitivity to AKT inhibitor-induced growth arrest
Activation of the Protein Kinase B (PKB), or AKT pathway has been shown to correlate with acute myeloid leukemia (AML) prognosis. B55α-Protein Phosphatase 2A (PP2A) has been shown to dephosphorylate AKT at Thr-308 rendering it inactive. In fact, low expression of the PP2A regulatory subunit B55α was...
Autores principales: | Shouse, Geoffrey, de Necochea-Campion, Rosalia, Mirshahidi, Saied, Liu, Xuan, Chen, Chien-Shing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308637/ https://www.ncbi.nlm.nih.gov/pubmed/27531894 http://dx.doi.org/10.18632/oncotarget.11209 |
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